| 2026 | RReview | Molecular switches of SQSTM1: the impact of post-translational modifications on autophagy and neurodegeneration ABR2026 Abrar F et al. · Autophagy |
| 2026 | AAnimal model | Disruption of the insulin/IGF-1 signaling pathway in Caenorhabditis elegans dramatically increases male longevity and enhances reproductive health late in life ALS2026 Al-Saadi RS et al. · Aging (Albany NY) |
| 2026 | RReview | Strengthening Muscle for Healthy Ageing: Innovative Treatments for Sarcopenia ANC2026 Ancel S et al. · Nature reviews. Drug discovery |
| 2026 | AAnimal model | Restriction of individual branched-chain amino acids has distinct effects on the development and progression of Alzheimer's disease in 3xTg mice BAB2025 Babygirija R et al. · Advanced Science |
| 2026 | RReview | Decoding the PI3K/Akt/mTOR-JAK/STAT signaling axis in multiple sclerosis: mechanistic crosstalk and therapeutic opportunities. BANERJEE2026 Banerjee C et al. · Immunologic research |
| 2026 | AAnimal model | Rapamycin-induced fatty liver in mice is attenuated by chloroquine co-treatment in an ERRα-dependent manner BCH2026 B'chir W et al. · Journal of Endocrinology |
| 2026 | MMolecular | Molecular and metabolic dysregulation of lung cancer in developing anti-tumor activity by gambogic acid mediated mTOR signaling: in vitro and computational study. BO2026 Bo S et al. · 3 Biotech |
| 2026 | RReview | Substrate-selective mTORC1 regulation and gene dosage-dependent tissue divergence in Birt-Hogg-Dubé syndrome CAO2026 Cao ZL et al. · Frontiers in Oncology |
| 2026 | AAnimal model | Dihydromyricetin attenuates fibrosis-associated features of hypertrophic scar with accompanying changes in PI3K/AKT/mTOR-related signaling. CAO2026B Cao P et al. · Frontiers in Pharmacology |
| 2026 | AAnimal model | Forsythoside A Alleviates Hypertensive Nephropathy by Promoting Mitophagy and Inhibiting Ferroptosis via ASCL1-CCNB1/mTOR Pathway. CUI2026 Cui X et al. · Journal of Ethnopharmacology |
| 2026 | MMolecular | mTORC1 inhibition upregulates CD20 and enhances anti-CD20 antibody efficacy in B-cell precursor acute lymphoblastic leukemia DAB2026 Dąbkowska A et al. · Leukemia |
| 2026 | MMolecular | ATF4 activates a transcriptional program that chronically suppresses mTOR activity and promotes neurodegeneration in Parkinson disease models DEMMINGS2026 Demmings MD et al. · Cell Reports |
| 2026 | AAnimal model | Spalt-related is an inhibitor of mTORC1-mediated growth activated by the integrated stress response DEN2026 Onur Deniz et al. · The EMBO Journal |
| 2026 | MMolecular | Transcriptional modulation of the PI3K/AKT/mTOR signaling pathway mediated by HPV16 oncogene expression in breast cancer. DEOLIVEIRA2026 de Oliveira Isidio BE et al. · Exploration of targeted anti-tumor therapy |
| 2026 | AAnimal model | Midlife Growth Hormone Receptor Ablation Extends Healthy Lifespan and Induces Sex-Specific Hepatic Transcriptional Changes at Single-Cell Resolution DUR2026 Duran-Ortiz S et al. · Aging cell |
| 2026 | MMolecular | PTEN regulates microtubule polymerization via mTORC2, but not mTORC1, in peripheral sensory neurons EVA2026 Evans S et al. · eNeuro |
| 2026 | MMolecular | mTOR inactivation governs adaptive survival to ribosome biogenesis deficiency FAN2026 Fan W et al. · Genes & Development |
| 2026 | MMolecular | tRNA-derived fragment tRF-17-8SPOL52 induces resistance to bortezomib in multiple myeloma via autophagy activation. FU2026 Fu Y et al. · Biochimica et biophysica acta. Molecular basis of disease |
| 2026 | MMolecular | Astragaloside IV Mitigates Tacrolimus-Induced Chronic Nephrotoxicity by Regulating the mTOR-TFEB-GADD45alpha Pathway GAO2026 Ping Gao et al. · Journal of Agricultural and Food Chemistry |
| 2026 | HHuman study | Tumor fat composition predicts response to everolimus and supports low-dose therapy in TSC-associated renal angiomyolipomas: a multicenter prospective study GAO2026B Gao K et al. · Frontiers in oncology |
| 2026 | HHuman study | Association of rapamycin treatment with the modulation of purine metabolism, reduced microglial inflammatory responses, improved mitochondrial energy metabolism, and alleviation of fatigue symptoms in ME/CFS subjects: pilot findings from phase-II observational study GIL2026 Brooke Gile et al. · Journal of Translational Medicine |
| 2026 | MMolecular | Inferring feedback regulation from static snapshots of a single signal GIN2026 Ginzberg M et al. · Biochemistry and Biophysics Reports |
| 2026 | MMolecular | A Systems Pharmacology Model of Aging Identifies Optimal Combination Therapies With Secondary Benefits on Weight Loss and Metabolic Health GOR2026 Goryanin I et al. · CPT Pharmacometrics Syst Pharmacol |
| 2026 | HHuman study | Maternal Sirolimus Therapy for Fetal Extensive Lymphatic Cystic Malformation: Selection Criteria, Management, and Outcomes in a Series of Six Cases GUIB2026 Guibaud L et al. · Prenatal Diagnosis |
| 2026 | AAnimal model | Melittin attenuates imiquimod-induced psoriatic dermatitis in mice: a role for autophagy activation via PI3K/Akt/mTOR pathway suppression. HAFEZ2026 Hafez SA et al. · Saudi pharmaceutical journal |
| 2026 | AAnimal model | An ANGPTL8-AKT2-mTOR Axis Drives Adipose Senescence and Aging-Related Functional Decline HE2026 He Y et al. · Aging Cell |
| 2026 | AAnimal model | Survival and Homeostasis of Alveolar Macrophages in Vivo Depend on mTOR Signaling HEN2026 Hennessy-Strahs S et al. · American Journal of Respiratory Cell and Molecular Biology |
| 2026 | MMolecular | Recurrent PIK3CA-E545K mutation promotes cervical cancer growth and invasion via AKT/mTOR signaling. HUANG2026 Huang C et al. · Molecular genetics and genomics |
| 2026 | AAnimal model | FGF21-modified adipose stem cell-derived exosomes promote wound healing by activating fibroblast glycolysis through AMPK/mTOR signaling. CHEN2026 Chen K et al. · Cellular signalling |
| 2026 | MMolecular | IGF2BP3-Mediated m6A Modification of OLR1 mRNA Promotes Immune Evasion in CRC via the PI3K/AKT/mTOR Pathway CHEN2026B Chen W · Journal of Immunotherapy |
| 2026 | AAnimal model | Impaired Chaperone-Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation CHEN2026C Chen Xianglong et al. · Advanced Science |
| 2026 | AAnimal model | Diet-dependent, beneficial and adverse effects of rapamycin on life span of Drosophila melanogaster JAC2026 Jackson LN et al. · GeroScience |
| 2026 | MMolecular | Rapamycin co-exposure fails to reduce cisplatin-induced damage in GC6-spg spermatogonial cell line. JIB2026 Jibrin A et al. · Reproduction & Fertility |
| 2026 | MMolecular | Redox-sensitive mTOR-eIF4A signaling promotes selective P-glycoprotein translation. JIN2026 Jin P et al. · Free radical biology & medicine |
| 2026 | AAnimal model | Rapamycin attenuates age-related atrial remodeling and fibrillation by targeting HIF-1α-mediated metabolic dysregulation. JIN2026B Jin L et al. · Biochimica et Biophysica Acta - Molecular Basis of Disease |
| 2026 | RReview | The hallmarks of protein and amino acid restriction in aging and longevity KNO2026 Knopf BA et al. · Cell Press Blue |
| 2026 | AAnimal model | Aging preserves mTORC1 but attenuates JNK-SMAD2L signaling sensitivity to passive stretch-induced tension development in isolated mouse skeletal muscle. KRISTIANSEN2026 Kristiansen JB et al. · Experimental gerontology |
| 2026 | MMolecular | CASTOR1 regulates humoral immune responses and contributes to the pathogenesis of systemic lupus erythematosus KUS2026 Kusuda T et al. · Arthritis & Rheumatology |
| 2026 | HHuman study | Does the duration of exposure to everolimus influence the occurrence of chronic lung allograft dysfunction? LANDOAS2026 Landoas A et al. · Transplant Immunology |
| 2026 | AAnimal model | Feeding-Induced Muscle mTORC1 Signaling Regulates Postprandial Protein Synthesis and Endurance but Not Muscle Size LAP2026 Lapp SC et al. · JCI insight |
| 2026 | HHuman study | Pregnane X receptor-mediated liver growth: a controlled clinical trial in healthy volunteers and identification of the role of AKT-MTOR pathway in mouse. LASSILA2026 Lassila P et al. · Archives of Toxicology |
| 2026 | AAnimal model | Aberrant excitatory neuronal ERBB4 promotes Alzheimer's disease pathology LEE2026 Lee SY et al. · Nature |
| 2026 | MMolecular | GPR143, a novel immunohistochemical marker for renal tumors with FLCN/TSC/MTOR-TFE alterations. LI2026 Li Q et al. · Virchows Archiv |
| 2026 | MMolecular | Brucella suis vaccine strain 2 promotes intracellular proliferation by inducing M2 macrophage polarization and autophagy through PI3K/Akt/mTOR signalling. LI2026B Li H et al. · Journal of Medical Microbiology |
| 2026 | MMolecular | LINP1 suppresses radiation-induced cellular senescence in keratinocytes by modulating the mTOR-p53 axis LIANG2026 Liang X et al. · Molecular and Cellular Biochemistry |
| 2026 | AAnimal model | Notoginsenoside R1 Alleviates Acetaminophen-Induced Liver Injury via MAPK/mTOR-Mediated Autophagy. LIS2026 Li S et al. · The American Journal of Chinese Medicine |
| 2026 | AAnimal model | Growth Hormone Receptor Antagonism Extends Lifespan LIST2026 List EO et al. · Aging cell |
| 2026 | MMolecular | Mathematical Modeling of Dietary Timing- and Protein Quality-Responsive Liver Circadian Clock and its Function on Ribosome Biogenesis LU2026 Lu L et al. · Physiological Genomics |
| 2026 | AAnimal model | Age-associated decline of Lamtor5 drives immunosenescence and systemic aging via cGAS-mediated paracrine inflammation. LV2026 Lv N et al. · Cell Death and Differentiation |
| 2026 | AAnimal model | Deubiquitinase USP7 stabilizes the histone demethylase KDM5B and promotes the progression of renal fibrosis through the TSC1/mTOR axis LV2026S Lv S et al. · Molecular biomedicine |
| 2026 | AAnimal model | PIP4K2A Attenuates Cerebral Ischemia/Reperfusion Injury by Reducing the TRIB3-p62 Complex Burden and Modulating AKT/mTOR Signaling. MA2026 Ma B et al. · Translational stroke research |
| 2026 | AAnimal model | Carvedilol attenuates PTZ-induced epileptogenesis: associations with hippocampal neuroinflammation and PI3K/AKT/mTOR-related alterations. MADKOUR2026 Madkour AH et al. · Scientific Reports |
| 2026 | HHuman study | EVERolimus effectiveness after proGREssion on ENdocrine therapy plus CDK4/6 inhibitor for ER-positive/HER2-negative advanced breast cancer: EVERGREEN study MAR2026 Diogo Martins-Branco et al. · Breast Cancer Research and Treatment |
| 2026 | AAnimal model | Constitutive mTORC1 Activation in Skeletal Muscle Increases Inflammation but is not Sufficient to Impair Glucose Tolerance. MARCHANT2026 Marchant ED et al. · Function (Oxford, England) |
| 2026 | HHuman study | Sirolimus is effective for paediatric Evans syndrome and secondary autoimmune cytopenias: A retrospective cohort study. MCNEILL2026 McNeill M et al. · British Journal of Haematology |
| 2026 | AAnimal model | Chronic Kidney Disease Risk Posed by 1-Ethoxy-2,3-difluoro-4-(trans-4-propylcyclohexyl) Benzene (EDPrB): An AOP of mTOR-Mediated Autophagy Dysregulation. MIAO2026 Miao C et al. · Environmental science & technology |
| 2026 | PPPreprint, not peer-reviewed | ER-Lysosome Cholesterol Exchange Regulates Lysosomal Motility Through mTOR-Dependent LAMTOR1 Phosphorylation MUT2026 Muthukottiappan P et al. · bioRxiv (preprint) |
| 2026 | AAnimal model | mTOR inhibition augments antitumor immune effector response by reprogramming the TP53-mutant, immune-cold HNSCC tumor microenvironment NAT2026 Nath P et al. · Neoplasia |
| 2026 | MMolecular | Disruption of hippocampal upstream regulators of mTOR and insulin pathways in Down syndrome with Alzheimer's disease neuropathology: Preliminary observations NOR2026 Nordbeck AJ et al. · Alzheimer's & Dementia |
| 2026 | AAnimal model | A cross-species drug-discovery platform to accelerate the identification of lifespan-extending interventions PEREZ2026 Perez K et al. · Cell Reports |
| 2026 | RReview | Biological limits of lifespan extension: evidence for a shift from pathway leverage to system-level buffering across species PIR2026 Denisa Fv Pirscoveanu et al. · Mechanisms of Ageing and Development |
| 2026 | MMolecular | Translational repression of 5' TOP mRNAs in chronically activated CD8+ T cells. PLEDGER2026 Pledger ES et al. · RNA biology |
| 2026 | MMolecular | An SLC7A5-dependent nutrient-sensing circuit overcomes cisplatin tolerance via mTOR-autophagy signaling. RAO2026 Rao P et al. · Biochemical and Biophysical Research Communications |
| 2026 | MMolecular | Tankyrase-2 regulates adipocyte differentiation through AMPK/mTOR signaling. RAUCH2026 Rauch B et al. · The FEBS journal |
| 2026 | AAnimal model | Microbiota-associated kynurenic acid drives PD-1 blockade resistance through an ITGA2-mTOR-CTSV axis in gastric cancer. REN2026 Ren Y et al. · Journal for immunotherapy of cancer |
| 2026 | MMolecular | "Trojan" Methionine Probe Reveals PKM2 as a Methionine-Sensing Protein in the mTORC1 Pathway SANG2026 Sang Z et al. · Journal of the American Chemical Society |
| 2026 | HHuman study | Everolimus for the treatment of neuropsychological deficits in tuberous sclerosis complex: findings from the TRON multicentre randomised controlled trial SAX2026 Saxena A et al. · Journal of medical genetics |
| 2026 | HHuman study | Sexual Dimorphism in Placental mTORC1 Signaling, Amino Acid Transport, and Mitochondrial Respiration at Term. SHIMADA2026 Shimada H et al. · Antioxidants |
| 2026 | AAnimal model | Enforcing mTORC1 activity in therapeutic CD4+ T cells promotes persistence but eventual immune exhaustion SIL2026 Sillito F et al. · Journal of Immunology |
| 2026 | AAnimal model | Urolithin A activates mitophagy via the AMPK-mTOR axis and modulates the gut-ceramide axis to ameliorate cardiac remodeling in HFpEF SONH2026 Hangyul Song et al. · Experimental and Molecular Medicine |
| 2026 | AAnimal model | Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila SRI2026 Sriskanthadevan-Pirahas S et al. · FEBS Lett |
| 2026 | AAnimal model | LncRNA DLX6-AS1 promotes necroptosis through PI3K/AKT/mTOR signaling pathway in myocardial ischemia/reperfusion injury mice SU2026 Su Y et al. · Scientific Reports |
| 2026 | HHuman study | Favorable response to second-line sirolimus regardless of status in acquired pure red cell aplasia: A retrospective study from a single center. SUN2026 Sun Z et al. · Therapeutic Advances in Hematology |
| 2026 | AAnimal model | Impaired mTOR/SREBP1-Mediated Lipogenesis as a Mechanism of Hepatic Glycogen Accumulation in a Carnivorous Fish Model, Largemouth Bass (Micropterus salmoides) TAO2026 Tao J et al. · FASEB Journal |
| 2026 | MMolecular | Firefox, a protein encoded by circular RNA circPVT1, is essential for MYC-driven oncogenesis TIW2026 Tiwari A et al. · Genes & Development |
| 2026 | MMolecular | FLCN loss is characterized by SQSTM1/p62 accumulation despite functional autophagy flux in Birt-Hogg-Dubé syndrome-associated kidney cancer ULL2026 Ullern H et al. · Autophagy Reports |
| 2026 | AAnimal model | Testosterone propionate maintains autophagic flux and mitochondrial integrity via regulation of the LC3B/p62/Beclin-1/mTOR axis in induced liver fibrosis. VER2026 Verma S et al. · Journal of Molecular Histology |
| 2026 | SSynthesis of human data | Efficacy and safety of everolimus in heart transplant recipients: A meta-analysis VITTE2026 Vitte SH et al. · JHLT Open |
| 2026 | HHuman study | [Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial. WALTER2026 Walter T et al. · Lancet |
| 2026 | MMolecular | Amino acid homeostasis by CORVET/HOPS: A metabolic and stress resilience checkpoint for T cells WANG2026 Wang J et al. · Proceedings of the National Academy of Sciences |
| 2026 | MMolecular | Pdcd4-Rictor interaction suppresses mTORC2-PFKFB3 axis and tumorigenesis in NSCLC. WANG2026B Wang Q et al. · Neoplasia |
| 2026 | MMolecular | Fluorescent protein ticker tape (FPTT): Multiplexed recording of transcriptional dynamics in living cells and in vivo WANG2026C Wang R et al. · Science Advances |
| 2026 | AAnimal model | Role of Autophagy in Scleral Remodeling During Form-Deprivation Myopia WEN2026 Wen J et al. · FASEB Journal |
| 2026 | RReview | Nutrient-sensing pathways in adult stem cells: Orchestrating homeostasis, aging, and disease XIA2026 Xiao T et al. · Seminars in Cell & Developmental Biology |
| 2026 | AAnimal model | Glutamine alleviates bisphenol A-induced jejunal injury in piglets involving mitochondrial function restoration and AMPK-mTOR signaling regulation. XIE2026 Xie J et al. · Ecotoxicology and Environmental Safety |
| 2026 | HHuman study | High Responsiveness of Head and Neck Kaposiform Hemangioendothelioma Without Kasabach-Merritt Phenomenon to Sirolimus Monotherapy. XU2026 Xu Y et al. · Pediatric Blood & Cancer |
| 2026 | AAnimal model | SLC15A3-mediated dipeptide metabolism confers antimetabolite resistance in lymphoma via mTORC1 activation. YAN2026 Yang X et al. · Journal of Clinical Investigation |
| 2026 | AAnimal model | Early-life exposure to polypropylene microplastics and DEHP induces ASD-relevant neurodevelopmental alterations involving mTOR-regulated autophagy impairment YANG2026 Yang G et al. · Ecotoxicology and Environmental Safety |
| 2026 | AAnimal model | Salvianolic Acid B Enhances Motor Function Recovery after Spinal Cord Injury in Association with AKT/mTOR/HIF-1α Pathway Activation and Angiogenesis. YAO2026 Yao J et al. · Biological & Pharmaceutical Bulletin |
| 2026 | MMolecular | Substrate recognition and transport mechanism of the human proton-coupled amino-acid transporter 1 (SLC36A1) YIN2026 Yin J et al. · Nature Communications |
| 2026 | AAnimal model | High-concentration hydrogen mitigates cognitive impairment in a murine model of Sepsis-associated encephalopathy by enhancing oligodendrocyte maturation and myelination in the mPFC YU2026 Yu J et al. · Progress in Neuro-Psychopharmacology and Biological Psychiatry |
| 2026 | AAnimal model | Pungenin Promotes Hair Growth in Mouse Models of Androgenic Alopecia Through Transcriptional Regulation of the PI3K/AKT/mTOR Axis. ZHAI2026 Zhai W et al. · Molecules |
| 2026 | AAnimal model | Non-canonical mTORC1-TFEB activation promotes hepatocyte plasticity and high-grade malignancy in hepatocellular carcinoma. ZHANG2026 Zhang C et al. · The Journal of clinical investigation |
| 2026 | AAnimal model | Dioscorea polystachya Turcz. attenuates male reproductive aging through modulation of mTOR-Beclin-1-mediated autophagy in Leydig and Sertoli cells ZHANG2026B Zhang Y et al. · Journal of Ethnopharmacology |
| 2026 | AAnimal model | Anti-breast cancer effects of the Xingxiao Pill are associated with inhibition of the ErbB3/PI3K/AKT/mTOR pathway, modulation of amino acid metabolism, and promotion of apoptosis. ZHANG2026C Zhang Jingyue et al. · Journal of Ethnopharmacology |
| 2026 | MMolecular | TET1-mediated DNA demethylation and transcription activation of MRPS17 induces lung adenocarcinoma through PI3K-AKT-mTOR pathway. ZHOU2026 Zhou N et al. · Journal of Molecular Histology |
| 2026 | AAnimal model | Corilagin attenuates osteoarthritis progression by coordinating NF-κB inhibition with PI3K/AKT/mTOR-associated autophagy restoration. ZHOU2026B Zhou R et al. · International Immunopharmacology |
| 2026 | AAnimal model | LKB1/AMPK deficiency aggravates mitochondrial DNA leakage via mTOR-dependent mitophagy damage in liver injury sensitized by trichloroethylene. ZHU2026 Zhu L et al. · Chemico-Biological Interactions |
| 2025 | RReview | What is the clinical evidence to support off-label rapamycin therapy in healthy adults? HAN2025 Hands JM et al. · Aging (Albany NY) |
| 2025 | RReview | mTORC1, the maestro of cell metabolism and growth HE2025 He L et al. · Genes & Development |
| 2025 | HHuman study | Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results MOE2025 Moel M et al. · Aging (Albany NY) |
| 2025 | HHuman study | The Bi-steric, mTORC1-Selective Inhibitor, RMC-5552, in Advanced Solid Tumors: A Phase 1 Trial SCH2025 Schram AM et al. · Clinical Cancer Research |
| 2024 | MMolecular | mTORC1 activity oscillates throughout the cell cycle, promoting mitotic entry and differentially influencing autophagy induction JOS2024 Joshi JN et al. · Cell Reports |
| 2024 | SSynthesis of human data | Targeting ageing with rapamycin and its derivatives in humans: a systematic review LEE2024 Lee DJW et al. · Lancet Healthy Longevity |
| 2024 | PPPreprint, not peer-reviewed | Targeting mTOR restores tau-induced metabolic, mitochondrial, and cognitive deficits in a tauopathy mouse model TAN2024 Tang Z et al. · bioRxiv (preprint) |
| 2023 | RReview | The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease GOU2023 Goul C et al. · Nature reviews. Molecular cell biology |
| 2023 | AAnimal model | A bi-steric mTORC1-selective inhibitor overcomes drug resistance in breast cancer MEN2023 Meng D et al. · Oncogene |
| 2022 | RReview | mTOR substrate phosphorylation in growth control BAT2022 Battaglioni S et al. · Cell |
| 2022 | AAnimal model | Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice STR2022 Strong R et al. · Aging Cell |
| 2022 | MMolecular | Structure of the nutrient-sensing hub GATOR2 VAL2022 Valenstein ML et al. · Nature |
| 2021 | MMolecular | Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction CON2021 Condon KJ et al. · Proceedings of the National Academy of Sciences of the United States of America |
| 2021 | HHuman study | Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials MAN2021 Mannick JB et al. · Lancet Healthy Longevity |
| 2021 | RReview | Regulation and metabolic functions of mTORC1 and mTORC2 SZW2021 Szwed A et al. · Physiological reviews |
| 2020 | MMolecular | AIMTOR, a BRET biosensor for live imaging, reveals subcellular mTOR signaling and dysfunctions BOU2020 Bouquier N et al. · BMC Biology |
| 2020 | RReview | mTOR at the nexus of nutrition, growth, ageing and disease LIU2020 Liu GY et al. · Nature Reviews Molecular Cell Biology |
| 2020 | MMolecular | A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dube syndrome NAP2020 Napolitano G et al. · Nature |
| 2020 | MMolecular | The 3.2-A resolution structure of human mTORC2 SCA2020 Scaiola A et al. · Science advances |
| 2019 | MMolecular | Architecture of human Rag GTPase heterodimers and their complex with mTORC1 ANA2019 Anandapadamanaban M et al. · Science |
| 2019 | RReview | The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism HOX2019 Hoxhaj G et al. · Nature reviews. Cancer |
| 2019 | HHuman study | Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial CHU2019 Chung CL et al. · GeroScience |
| 2019 | RReview | mTOR as a central hub of nutrient signalling and cell growth KIM2019 Kim J et al. · Nature cell biology |
| 2019 | MMolecular | Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex LAW2019 Lawrence RE et al. · Science |
| 2019 | MMolecular | Structural basis for the docking of mTORC1 on the lysosomal surface ROG2019 Rogala KB et al. · Science |
| 2019 | MMolecular | Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex SHE2019 Shen K et al. · Cell |
| 2019 | RReview | Molecular logic of mTORC1 signalling as a metabolic rheostat VAL2019 Valvezan AJ et al. · Nature metabolism |
| 2018 | MMolecular | Cryo-EM structure of human mTOR complex 2 CHE2018 Chen Xizi et al. · Cell research |
| 2018 | HHuman study | A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort KRA2018 Kraig E et al. · Experimental Gerontology |
| 2018 | MMolecular | A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase-Ragulator lysosomal scaffold LAW2018 Lawrence RE et al. · Nature cell biology |
| 2018 | MMolecular | Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state LEI2018 Lei HT et al. · Nature structural & molecular biology |
| 2018 | HHuman study | TORC1 inhibition enhances immune function and reduces infections in the elderly MAN2018 Mannick JB et al. · Science Translational Medicine |
| 2018 | RReview | mTOR signalling and cellular metabolism are mutual determinants in cancer MOS2018 Mossmann D et al. · Nature reviews. Cancer |
| 2018 | MMolecular | Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes SHE2018 Shen K et al. · Nature |
| 2018 | MMolecular | Architecture of the human mTORC2 core complex STU2018 Stuttfeld E et al. · eLife |
| 2017 | MMolecular | SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway GU2017 Gu X et al. · Science |
| 2017 | AAnimal model | mTORC2 Promotes Tumorigenesis via Lipid Synthesis GUR2017 Guri Y et al. · Cancer cell |
| 2017 | MMolecular | Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex HOW2017 Howell JJ et al. · Cell Metabolism |
| 2017 | MMolecular | Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2 KAR2017 Karuppasamy M et al. · Nature communications |
| 2017 | AAnimal model | Caloric restriction improves health and survival of rhesus monkeys MAT2017 Mattison JA et al. · Nature Communications |
| 2017 | MMolecular | SZT2 dictates GATOR control of mTORC1 signalling PEN2017 Peng M et al. · Nature |
| 2017 | RReview | Twenty-five years of mTOR: Uncovering the link from nutrients to growth SAB2017 Sabatini DM · Proceedings of the National Academy of Sciences of the United States of America |
| 2017 | RReview | mTOR Signaling in Growth, Metabolism, and Disease SAX2017 Saxton RA et al. · Cell |
| 2017 | MMolecular | Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex SUX2017 Su MY et al. · Molecular cell |
| 2017 | AAnimal model | A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs URF2017 Urfer SR et al. · GeroScience |
| 2017 | MMolecular | mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability VAL2017 Valvezan AJ et al. · Cancer cell |
| 2017 | MMolecular | KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1 WOL2017 Wolfson RL et al. · Nature |
| 2017 | RReview | The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway WOLF2017 Wolfson RL et al. · Cell metabolism |
| 2017 | MMolecular | mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient WYA2017 Wyant GA et al. · Cell |
| 2017 | MMolecular | Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40 YAN2017 Yang H et al. · Nature |
| 2016 | MMolecular | Tor forms a dimer through an N-terminal helical solenoid with a complex topology BAR2016 Baretic D et al. · Nature communications |
| 2016 | MMolecular | mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle BEN2016 Ben-Sahra I et al. · Science |
| 2016 | AAnimal model | Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice BIT2016 Bitto A et al. · eLife |
| 2016 | MMolecular | Lysosomal recruitment of TSC2 is a universal response to cellular stress DEM2016 Demetriades C et al. · Nature communications |
| 2016 | RReview | Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot GOB2016 Goberdhan DC et al. · Cell metabolism |
| 2016 | RReview | mTOR Signaling Confers Resistance to Targeted Cancer Drugs GUR2016 Guri Y et al. · Trends in cancer |
| 2016 | MMolecular | The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway CHA2016 Chantranupong L et al. · Cell |
| 2016 | RReview | The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging KEN2016 Kennedy BK et al. · Cell Metabolism |
| 2016 | MMolecular | Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor ROD2016 Rodrik-Outmezguine VS et al. · Nature |
| 2016 | HHuman study | Safety of two-year caloric restriction in non-obese healthy individuals ROM2016 Romashkan SV et al. · Oncotarget |
| 2016 | MMolecular | Mechanism of arginine sensing by CASTOR1 upstream of mTORC1 SAX2016 Saxton RA et al. · Nature |
| 2015 | AAnimal model | Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system ARR2015 Arriola Apelo SI et al. · Aging cell |
| 2015 | MMolecular | Architecture of human mTOR complex 1 AYL2015 Aylett CH et al. · Science |
| 2015 | RReview | Regulation of mTORC1 by PI3K signaling DIB2015 Dibble CC et al. · Trends in cell biology |
| 2015 | MMolecular | Metabolism. Differential regulation of mTORC1 by leucine and glutamine JEW2015 Jewell JL et al. · Science |
| 2015 | MMolecular | Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9 JUN2015 Jung J et al. · Molecular and cellular biology |
| 2015 | MMolecular | mTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation LAB2015 Laberge RM et al. · Nature Cell Biology |
| 2015 | MMolecular | PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex LIU2015 Liu P et al. · Cancer discovery |
| 2015 | MMolecular | SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1 REB2015 Rebsamen M et al. · Nature |
| 2015 | MMolecular | Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway SAX2015 Saxton RA et al. · Science |
| 2015 | MMolecular | Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1 WAN2015 Wang S et al. · Science |
| 2015 | MMolecular | Sestrin2 is a leucine sensor for the mTORC1 pathway WOL2015 Wolfson RL et al. · Science |
| 2014 | HHuman study | Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls BAN2014 Bannister CA et al. · Diabetes, Obesity and Metabolism |
| 2014 | MMolecular | Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2 DEM2014 Demetriades C et al. · Cell |
| 2014 | AAnimal model | Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome FOK2014 Fok WC et al. · PloS one |
| 2014 | MMolecular | A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity GRA2014 Grabiner BC et al. · Cancer discovery |
| 2014 | AAnimal model | Acarbose, 17-alpha-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males HAR2014 Harrison DE et al. · Aging Cell |
| 2014 | MMolecular | The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1 CHA2014 Chantranupong L et al. · Cell reports |
| 2014 | HHuman study | mTOR inhibition improves immune function in the elderly MAN2014 Mannick JB et al. · Science Translational Medicine |
| 2014 | MMolecular | Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome MEN2014 Menon S et al. · Cell |
| 2014 | AAnimal model | Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction MIL2014 Miller RA et al. · Aging cell |
| 2014 | MMolecular | Sestrins inhibit mTORC1 kinase activation through the GATOR complex PAR2014 Parmigiani A et al. · Cell reports |
| 2014 | RReview | Mammalian target of rapamycin signaling in cardiac physiology and disease SCI2014 Sciarretta S et al. · Circulation research |
| 2014 | RReview | Making new contacts: the mTOR network in metabolism and signalling crosstalk SHI2014 Shimobayashi M et al. · Nature reviews. Molecular cell biology |
| 2014 | AAnimal model | The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice SOL2014 Solon-Biet SM et al. · Cell Metabolism |
| 2014 | HHuman study | Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib WAG2014 Wagle N et al. · Cancer discovery |
| 2013 | MMolecular | A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1 BAR2013 Bar-Peled L et al. · Science |
| 2013 | MMolecular | Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1 BEN2013 Ben-Sahra I et al. · Science |
| 2013 | MMolecular | mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology BET2013 Betz C et al. · Proceedings of the National Academy of Sciences of the United States of America |
| 2013 | RReview | Where is mTOR and what is it doing there? BETZ2013 Betz C et al. · The Journal of cell biology |
| 2013 | HHuman study | Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial BIS2013 Bissler JJ et al. · Lancet |
| 2013 | RReview | Signal integration by mTORC1 coordinates nutrient input with biosynthetic output DIB2013 Dibble CC et al. · Nature cell biology |
| 2013 | AAnimal model | Late-life rapamycin treatment reverses age-related heart dysfunction FLY2013 Flynn JM et al. · Aging Cell |
| 2013 | HHuman study | Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial FRA2013 Franz DN et al. · Lancet |
| 2013 | AAnimal model | mTORC2 controls actin polymerization required for consolidation of long-term memory HUA2013 Huang W et al. · Nature Neuroscience |
| 2013 | RReview | mTOR is a key modulator of ageing and age-related disease JOH2013 Johnson SC et al. · Nature |
| 2013 | MMolecular | mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation MOR2013 Morita M et al. · Cell metabolism |
| 2013 | MMolecular | mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6 NAZ2013 Nazio F et al. · Nature cell biology |
| 2013 | AAnimal model | Rapamycin extends murine lifespan but has limited effects on aging NEF2013 Neff F et al. · The Journal of clinical investigation |
| 2013 | MMolecular | Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1 PAN2013 Panchaud N et al. · Science signaling |
| 2013 | MMolecular | Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases PET2013 Petit CS et al. · The Journal of cell biology |
| 2013 | HHuman study | High-dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition POU2013 Poulsen MM et al. · Diabetes |
| 2013 | AAnimal model | Overexpression of Atg5 in mice activates autophagy and extends lifespan PYO2013 Pyo JO et al. · Nature Communications |
| 2013 | MMolecular | Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis ROB2013 Robitaille AM et al. · Science |
| 2013 | AAnimal model | Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation SIN2013 Sinclair LV et al. · Nature immunology |
| 2013 | MMolecular | The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1 TSU2013 Tsun ZY et al. · Molecular cell |
| 2013 | AAnimal model | Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression WUX2013 Wu JJ et al. · Cell reports |
| 2013 | MMolecular | mTOR kinase structure, mechanism and regulation YAN2013 Yang H et al. · Nature |
| 2013 | AAnimal model | mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function ZEN2013 Zeng H et al. · Nature |
| 2012 | MMolecular | Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1 BAR2012 Bar-Peled L et al. · Cell |
| 2012 | HHuman study | Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer (BOLERO-2) BAS2012 Baselga J et al. · New England Journal of Medicine |
| 2012 | MMolecular | TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1 DIB2012 Dibble CC et al. · Molecular cell |
| 2012 | MMolecular | Glutaminolysis activates Rag-mTORC1 signaling DUR2012 Duran RV et al. · Molecular cell |
| 2012 | AAnimal model | Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival EFE2012 Efeyan A et al. · Nature |
| 2012 | AAnimal model | Chronic inhibition of mTOR by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice HAL2012 Halloran J et al. · Neuroscience |
| 2012 | MMolecular | Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway HAN2012 Han JM et al. · Cell |
| 2012 | MMolecular | The translational landscape of mTOR signalling steers cancer initiation and metastasis HSI2012 Hsieh AC et al. · Nature |
| 2012 | RReview | Regulation and function of mTOR signalling in T cell fate decisions CHI2012 Chi H · Nature reviews. Immunology |
| 2012 | HHuman study | Genome sequencing identifies a basis for everolimus sensitivity IYE2012 Iyer G et al. · Science |
| 2012 | MMolecular | SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling KIM2012 Kim YM et al. · Molecular cell |
| 2012 | AAnimal model | Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity LAM2012 Lamming DW et al. et al. · Science |
| 2012 | RReview | mTOR signaling in growth control and disease LAP2012 Laplante M et al. · Cell |
| 2012 | MMolecular | MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB MAR2012 Martina JA et al. · Autophagy |
| 2012 | AAnimal model | TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO ROB2012 Robida-Stubbs S et al. · Cell metabolism |
| 2012 | MMolecular | The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis ROC2012 Roczniak-Ferguson A et al. · Science signaling |
| 2012 | MMolecular | A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB SET2012 Settembre C et al. · The EMBO journal |
| 2012 | AAnimal model | Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice STR2012 Strong R et al. · J Gerontol A Biol Sci Med Sci |
| 2012 | MMolecular | A unifying model for mTORC1-mediated regulation of mRNA translation THO2012 Thoreen CC et al. · Nature |
| 2012 | AAnimal model | Rapamycin slows aging in mice WIL2012 Wilkinson JE et al. · Aging Cell |
| 2011 | AAnimal model | The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2 DEL2011 Delgoffe GM et al. · Nature immunology |
| 2011 | MMolecular | Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate GAN2011 Gan X et al. · The Journal of biological chemistry |
| 2011 | MMolecular | The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling HSU2011 Hsu PP et al. · Science |
| 2011 | MMolecular | AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 KIM2011 Kim J et al. · Nature Cell Biology |
| 2011 | MMolecular | Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop LOF2011 Löffler AS et al. · Autophagy |
| 2011 | HHuman study | Efficacy and safety of sirolimus in lymphangioleiomyomatosis (MILES) MCC2011 McCormack FX et al. · New England Journal of Medicine |
| 2011 | AAnimal model | Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice MIL2011 Miller RA et al. · J Gerontol A Biol Sci Med Sci |
| 2011 | MMolecular | mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway PET2011 Peterson TR et al. · Cell |
| 2011 | RReview | Regulation of immune responses by mTOR POW2011 Powell JD et al. · Annual review of immunology |
| 2011 | MMolecular | mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling ROD2011 Rodrik-Outmezguine VS et al. · Cancer discovery |
| 2011 | MMolecular | Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size SAC2011 Saci A et al. · Molecular cell |
| 2011 | MMolecular | TFEB links autophagy to lysosomal biogenesis SET2011 Settembre C et al. · Science |
| 2011 | AAnimal model | The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation WAN2011 Wang R et al. · Immunity |
| 2011 | HHuman study | Everolimus for advanced pancreatic neuroendocrine tumors (RADIANT-3) YAO2011 Yao JC et al. · New England Journal of Medicine |
| 2011 | MMolecular | Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling YUX2011 Yu Yonghao et al. · Science |
| 2011 | MMolecular | Activation of mTORC2 by association with the ribosome ZIN2011 Zinzalla V et al. · Cell |
| 2011 | MMolecular | mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase ZON2011 Zoncu R et al. · Science |
| 2010 | AAnimal model | Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster BJE2010 Bjedov I et al. · Cell Metabolism |
| 2010 | AAnimal model | Molecular interplay between mTOR, amyloid-beta, and Tau: effects on cognitive impairments CAC2010 Caccamo A et al. · Journal of Biological Chemistry |
| 2010 | MMolecular | Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy EGA2010 Egan DF et al. · Science |
| 2010 | RReview | Extending healthy life span--from yeast to humans FON2010 Fontana L et al. · Science |
| 2010 | AAnimal model | Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state FOR2010 Foretz M et al. · The Journal of Clinical Investigation |
| 2010 | MMolecular | Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E HSI2010 Hsieh AC et al. · Cancer cell |
| 2010 | MMolecular | Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor JAN2010 Janes MR et al. · Nature medicine |
| 2010 | MMolecular | Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner KAL2010 Kalender A et al. · Cell Metabolism |
| 2010 | HHuman study | Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis KRU2010 Krueger DA et al. · New England Journal of Medicine |
| 2010 | AAnimal model | Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies LEE2010 Lee JH et al. · Science |
| 2010 | AAnimal model | mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists LIX2010 Li N et al. · Science |
| 2010 | MMolecular | Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids SAN2010 Sancak Y et al. · Cell |
| 2010 | MMolecular | mTORC1 controls fasting-induced ketogenesis and its modulation by ageing SEN2010 Sengupta S et al. · Nature |
| 2010 | AAnimal model | Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease SPI2010 Spilman P et al. · PLoS ONE |
| 2010 | MMolecular | Termination of autophagy and reformation of lysosomes regulated by mTOR YUX2010 Yu L et al. · Nature |
| 2010 | RReview | mTOR: from growth signal integration to cancer, diabetes and ageing ZON2010 Zoncu R et al. · Nature reviews. Molecular cell biology |
| 2009 | AAnimal model | mTOR regulates memory CD8 T-cell differentiation ARA2009 Araki K et al. · Nature |
| 2009 | AAnimal model | mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging CAS2009 Castilho RM et al. · Cell stem cell |
| 2009 | MMolecular | The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment DEL2009 Delgoffe GM et al. · Immunity |
| 2009 | MMolecular | Rapamycin decelerates cellular senescence DEM2009 Demidenko ZN et al. · Cell Cycle |
| 2009 | HHuman study | Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis DRU2009 Drummond MJ et al. · Journal of Physiology |
| 2009 | MMolecular | Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2 FEL2009 Feldman ME et al. · PLoS Biology |
| 2009 | MMolecular | ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy GAN2009 Ganley IG et al. · The Journal of biological chemistry |
| 2009 | MMolecular | Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR) GAR2009 Garcia-Martinez JM et al. · The Biochemical journal |
| 2009 | AAnimal model | mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice GUE2009 Guertin DA et al. · Cancer cell |
| 2009 | AAnimal model | Rapamycin fed late in life extends lifespan in genetically heterogeneous mice HAR2009 Harrison DE et al. · Nature |
| 2009 | MMolecular | Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy HOS2009 Hosokawa N et al. · Molecular Biology of the Cell |
| 2009 | AAnimal model | mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells CHE2009 Chen C et al. · Science signaling |
| 2009 | MMolecular | AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity CHR2009 Chresta CM et al. · Cancer research |
| 2009 | RReview | Molecular mechanisms of mTOR-mediated translational control MAX2009 Ma XM et al. · Nature reviews. Molecular cell biology |
| 2009 | MMolecular | DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival PET2009 Peterson TR et al. · Cell |
| 2009 | AAnimal model | Ribosomal protein S6 kinase 1 signaling regulates mammalian life span SEL2009 Selman C et al. · Science |
| 2009 | MMolecular | An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1 THO2009 Thoreen CC et al. · Journal of Biological Chemistry |
| 2009 | AAnimal model | Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice ZHO2009 Zhou J et al. · The Journal of neuroscience |
| 2009 | AAnimal model | 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila ZID2009 Zid BM et al. · Cell |
| 2008 | AAnimal model | Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy BEN2008 Bentzinger CF et al. · Cell metabolism |
| 2008 | HHuman study | Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis BIS2008 Bissler JJ et al. · The New England journal of medicine |
| 2008 | MMolecular | Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer CAR2008 Carracedo A et al. · The Journal of clinical investigation |
| 2008 | AAnimal model | Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis EHN2008 Ehninger D et al. · Nature medicine |
| 2008 | MMolecular | mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1) GAR2008 Garcia-Martinez JM et al. · The Biochemical journal |
| 2008 | MMolecular | AMPK phosphorylation of raptor mediates a metabolic checkpoint GWI2008 Gwinn DM et al. · Molecular Cell |
| 2008 | AAnimal model | TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species CHE2008 Chen C et al. · Journal of Experimental Medicine |
| 2008 | MMolecular | Regulation of TORC1 by Rag GTPases in nutrient response KIM2008 Kim E et al. · Nature cell biology |
| 2008 | AAnimal model | Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function MEI2008 Meikle L et al. · The Journal of neuroscience |
| 2008 | HHuman study | Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial MOT2008 Motzer RJ et al. · Lancet |
| 2008 | AAnimal model | Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration POL2008 Polak P et al. · Cell metabolism |
| 2008 | MMolecular | SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth POR2008 Porstmann T et al. · Cell metabolism |
| 2008 | MMolecular | The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1 SAN2008 Sancak Y et al. · Science |
| 2008 | MMolecular | The TSC-mTOR signaling pathway regulates the innate inflammatory response WEI2008 Weichhart T et al. · Immunity |
| 2007 | MMolecular | mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex CUN2007 Cunningham JT et al. · Nature |
| 2007 | RReview | Defining the role of mTOR in cancer GUE2007 Guertin DA et al. · Cancer Cell |
| 2007 | HHuman study | Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma HUD2007 Hudes G et al. · New England Journal of Medicine |
| 2007 | MMolecular | The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1 OSH2007 Oshiro N et al. · The Journal of biological chemistry |
| 2007 | MMolecular | PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase SAN2007 Sancak Y et al. · Molecular Cell |
| 2007 | MMolecular | Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40 VAN2007 Vander Haar E et al. · Nature cell biology |
| 2006 | RReview | Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition BLA2006 Blagosklonny MV · Cell Cycle |
| 2006 | MMolecular | S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth DOR2006 Dorrello NV et al. · Science |
| 2006 | MMolecular | mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s FRI2006 Frias MA et al. · Current biology : CB |
| 2006 | MMolecular | Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1 GUE2006 Guertin DA et al. · Developmental Cell |
| 2006 | MMolecular | TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth INO2006 Inoki K et al. · Cell |
| 2006 | MMolecular | SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity JAC2006 Jacinto E et al. · Cell |
| 2006 | MMolecular | mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt ORE2006 O'Reilly KE et al. · Cancer research |
| 2006 | AAnimal model | Extension of chronological life span in yeast by decreased TOR pathway signaling POW2006 Powers RW et al. · Genes & development |
| 2006 | MMolecular | Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB SAR2006 Sarbassov DD et al. · Molecular Cell |
| 2006 | RReview | TOR signaling in growth and metabolism WUL2006 Wullschleger S et al. · Cell |
| 2006 | MMolecular | Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity YAN2006 Yang Q et al. · Genes & development |
| 2005 | MMolecular | mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events HOL2005 Holz MK et al. · Cell |
| 2005 | AAnimal model | Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients KAE2005 Kaeberlein M et al. · Science |
| 2005 | MMolecular | Rheb binds and regulates the mTOR kinase LON2005 Long X et al. · Current biology : CB |
| 2005 | MMolecular | Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis MA2005 Ma L et al. · Cell |
| 2005 | MMolecular | Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex SAR2005 Sarbassov DD et al. · Science |
| 2004 | MMolecular | Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex BRU2004 Brugarolas J et al. · Genes & development |
| 2004 | MMolecular | The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins HAR2004 Harrington LS et al. · The Journal of Cell Biology |
| 2004 | MMolecular | Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive JAC2004 Jacinto E et al. · Nature cell biology |
| 2004 | AAnimal model | Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway KAP2004 Kapahi P et al. · Current Biology |
| 2004 | AAnimal model | mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways MAJ2004 Majumder PK et al. · Nature medicine |
| 2004 | AAnimal model | Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease RAV2004 Ravikumar B et al. · Nature Genetics |
| 2004 | MMolecular | Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton SAR2004 Sarbassov DD et al. · Current Biology |
| 2004 | MMolecular | Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies SHA2004 Shah OJ et al. · Current Biology |
| 2004 | MMolecular | The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress SHW2004 Shaw RJ et al. · Proceedings of the National Academy of Sciences |
| 2004 | AAnimal model | Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity UMX2004 Um SH et al. · Nature |
| 2003 | MMolecular | Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2 GAR2003 Garami A et al. · Molecular cell |
| 2003 | MMolecular | TSC2 mediates cellular energy response to control cell growth and survival INO2003 Inoki K et al. · Cell |
| 2003 | MMolecular | Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling INOK2003 Inoki K et al. · Genes & development |
| 2003 | MMolecular | GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR KIM2003 Kim DH et al. · Molecular Cell |
| 2003 | AAnimal model | Autophagy genes are essential for dauer development and life-span extension in C. elegans MEL2003 Melendez A et al. · Science |
| 2003 | MMolecular | The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif NOJ2003 Nojima H et al. · The Journal of biological chemistry |
| 2003 | MMolecular | Rheb promotes cell growth as a component of the insulin/TOR signalling network SAU2003 Saucedo LJ et al. · Nature cell biology |
| 2003 | MMolecular | TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function SCH2003 Schalm SS et al. · Current biology : CB |
| 2003 | MMolecular | Rheb is an essential regulator of S6K in controlling cell growth in Drosophila STO2003 Stocker H et al. · Nature cell biology |
| 2003 | MMolecular | Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb TEE2003 Tee AR et al. · Current Biology |
| 2003 | AAnimal model | Genetics: influence of TOR kinase on lifespan in C. elegans VEL2003 Vellai T et al. · Nature |
| 2002 | RReview | The phosphoinositide 3-kinase pathway CAN2002 Cantley LC · Science |
| 2002 | MMolecular | Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E FIN2002 Fingar DC et al. · Genes & development |
| 2002 | MMolecular | Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action HARA2002 Hara K et al. · Cell |
| 2002 | MMolecular | TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling INO2002 Inoki K et al. · Nature Cell Biology |
| 2002 | MMolecular | mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery KIM2002 Kim DH et al. · Cell |
| 2002 | MMolecular | Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control LOE2002 Loewith R et al. · Molecular cell |
| 2001 | AAnimal model | Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo BOD2001 Bodine SC et al. · Nature cell biology |
| 2001 | MMolecular | Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways ROM2001 Rommel C et al. · Nature Cell Biology |
| 2001 | MMolecular | Role of AMP-activated protein kinase in mechanism of metformin action ZHO2001 Zhou G et al. · J Clin Invest |
| 2000 | HHuman study | Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study KAH2000 Kahan BD (Rapamune US Study Group) · Lancet |
| 1999 | MMolecular | Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor BRU1999 Brunet A et al. · Cell |
| 1999 | MMolecular | Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism GIN1999 Gingras AC et al. · Genes & development |
| 1998 | MMolecular | RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1 BUR1998 Burnett PE et al. · Proceedings of the National Academy of Sciences of the United States of America |
| 1998 | MMolecular | Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism HAR1998 Hara K et al. · The Journal of biological chemistry |
| 1997 | MMolecular | Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin BRU1997 Brunn GJ et al. · Science |
| 1996 | AAnimal model | Dwarf mice and the ageing process BRO1996 Brown-Borg HM et al. · Nature |
| 1996 | MMolecular | Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP CHO1996 Choi J et al. · Science |
| 1995 | MMolecular | Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells SAB1995 Sabers CJ et al. · The Journal of biological chemistry |
| 1994 | MMolecular | A mammalian protein targeted by G1-arresting rapamycin-receptor complex BRO1994 Brown EJ et al. · Nature |
| 1994 | MMolecular | RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs SAB1994 Sabatini DM et al. · Cell |
| 1992 | MMolecular | Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases CHU1992 Chung J et al. · Cell |
| 1992 | MMolecular | Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase KUO1992 Kuo CJ et al. · Nature |
| 1992 | MMolecular | Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase PRI1992 Price DJ et al. · Science |
| 1991 | MMolecular | Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast HEI1991 Heitman J et al. · Science |
| 1975 | MMolecular | Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle VEZ1975 Vezina C et al. · Journal of Antibiotics |
| — | RTRegistered trial, no results yet | Everolimus Aging Study (EVERLAST): Clinical Evaluation of mTORC1 Inhibition for Geroprotection NCT05835999 University of Wisconsin et al. · ClinicalTrials.gov (registration) |