GPR143 is a sensitive and specific immunohistochemical biomarker for renal tumors driven by FLCN/TSC/MTOR-TFE pathway alterations, offering a practical diagnostic tool beyond existing ancillary tests.
| Evidence tier | D Mechanistic / in vitro / review |
| Study type | 5 - Mechanistic / In Vitro |
| Model system | Human tissue (renal tumor specimens) |
| Journal | Virchows Archiv |
| Year | 2026 |
| Peer reviewed | Yes |
| Source | DOI 10.1007/s00428-026-04646-4 · PMID 42463886 |
Diagnosis of MiT/TFE family translocation renal cell carcinoma is challenging. This study identifies GPR143 as a novel immunohistochemical marker that reliably identifies renal tumors harboring FLCN/TSC/mTOR-TFE pathway alterations, offering a practical diagnostic aid.
| Intervention | GPR143 immunohistochemistry |
| Target | MTOR / FLCN / TSC pathway in renal cell carcinoma |
| Model | Human |
| Effect | GPR143 overexpression identifies mTOR-pathway-driven renal tumors; positive diagnostic marker |