What the Atlas can answer, and what it can't
Ten questions written up in plain language, ten that the evidence can't settle yet, and the words you need to read either. Every answer says what kind of study stands behind each claim.
10 written answers · 10 open questions · 25 glossary terms · 518 studies underneath
- 01 Questions the Atlas has answered10 answers Start here. Under each question, one square for every key study the answer
rests on, coloured by the kind of study, so you can see at a glance which answers stand on human
data and which on mice.
- 01 Does rapamycin extend lifespan in humans? 7 key studies Key studies by code: S 1, H 3, A 2, M 1
- 02 mTORC1 vs mTORC2 – what's the difference? 1 key study · all M Key studies by code: M 1
- 03 What are mTOR inhibitors? The full list, by mechanism 6 key studies Key studies by code: H 3, A 1, M 2
- 04 What are rapamycin's side effects? 6 key studies Key studies by code: H 5, M 1
- 05 What do we know about whether autophagy drives the lifespan benefit? 6 key studies · all A Key studies by code: A 6
- 06 How is rapamycin dosed in the longevity studies? 4 key studies Key studies by code: H 2, A 2
- 07 What is mTOR? 3 key studies · all M Key studies by code: M 3
- 08 Rapamycin vs metformin – how do they compare for longevity? 2 key studies Key studies by code: S 1, H 1
- 09 Are sirolimus and everolimus the same drug? 6 key studies Key studies by code: S 1, H 5
- 10 How does mTOR connect to cancer? 6 key studies · all H Key studies by code: H 6
- 02 What the evidence can't answer yet10 open questions · 7 frontier Where the studies run out, the Atlas says so instead of guessing, and names why. Mechanism-to-outcome gap 4Contradiction / tension 4Human-endpoint gap 1Evidence desert 1 For example“Sensor-selective geroprotection without the metabolic penalty”
- 03 Glossary25 terms The vocabulary papers take for granted, explained plainly. Size shows how many
Atlas studies use the term.
mTORC1mTORRapamycinAutophagymTORC2EverolimusCellular senescenceTuberous sclerosis complexMetforminResveratrolRapalogTSC1/TSC2AMPKAkt/PKB4E-BP1S6K1RaptorRictorRhebRag GTPasesTFEBLysosomeCaloric restrictionInsulin resistanceEvidence code
- 04 Ask from your own AI assistantread-only API · MCP server The same questions, put to the same records from any assistant that speaks MCP,
or from your own code. Every study comes back with its evidence code, so a mouse result can't pass
for a human one. What comes back: the 7 key studies behind this answer S Synthesis of human data1H Human study3A Animal model2M Molecular — cells, biochemistry, structure1 113 rapamycin studies labelled by the kind of study behind each – what's proven in mice, what's only measured as biomarkers in humans, and what's still an open question.
Does rapamycin extend lifespan in humans?
→ search_studies(…)
→ studies, each with its evidence code
Looking for one paper? Browse all 518 studies → search by title, author or DOI; filter by evidence code
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