The mTOR pathway, node by node

One curated model, two forms. Explore it below, or read it out: 11 guided walks and every one of the 138 interactions, each with the evidence behind it.

1. 01 · You are here The map 100 nodes · 138 links · 13 loops Open below ↓
2. 02 Guided routes 11 routes · one question each
   • How does a cell know it has enough raw material to grow?
   • How does a cell learn that it is allowed to grow?
   • Why doesn't rapamycin switch mTOR off completely?
   • + 8 more routes →
3. 03 Timing 76 regimens · 7 intermittent The axis the maps leave out: how a drug was given over time, and which links depend on it. Pattern vs average · 18 studies →
4. 04 All 138 interactions best evidence per link H 14A 41M 83 Every link with the conditions it holds under. 8 have conflicting studies.

Map and text are the same model (pathway/model.json) — 100 nodes, 138 interactions, 13 feedback loops. The reading-level switch applies to both.

The eleven guided routes, written out step by step →

All 138 interactions

The full table of every modelled interaction, with mechanism, the condition each holds under and the evidence behind it, now has its own page.

All 138 interactions, in a table →