De novo synthesis of fatty acids and cholesterol via SREBP. A growing cell needs membrane as much as it needs protein; both mTOR complexes feed this.
Making fat and membrane.
mTORC1 acts via SREBP; mTORC2 contributes independently in liver, which is why hepatic Rictor loss and hepatic Raptor loss give different lipid phenotypes.
| Tier | What it means | Studies |
|---|---|---|
| C | Animal in vivo | 1 |
| D | Mechanistic / in vitro / review | 3 |
No direct human evidence in the Atlas for this entity yet — everything below rests on animal or mechanistic work.
| Study | Year | Tier | Finding |
|---|---|---|---|
| GUR2017 | 2017 | C | mTORC2 promotes tumorigenesis through control of de novo lipid synthesis. |
| SHI2014 | 2014 | D | Review of the mTOR network in metabolism and signalling crosstalk. |
| PET2011 | 2011 | D | mTORC1 controls lipin-1 nuclear localization to regulate SREBP and lipid synthesis. |
| POR2008 | 2008 | D | mTORC1 activates SREBP to drive lipogenesis supporting Akt-dependent cell growth. |