mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway

Peterson TR, Sabatini DM et al. · 2011 · Cell · Atlas ID PET2011

What this study shows

mTORC1 controls lipin-1 nuclear localization to regulate SREBP and lipid synthesis.

Abstract

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The nutrient- and growth factor-responsive kinase mTOR complex 1 (mTORC1) regulates many processes that control growth, including protein synthesis, autophagy, and lipogenesis. Through unknown mechanisms, mTORC1 promotes the function of SREBP, a master regulator of lipo- and sterolgenic gene transcription. Here, we demonstrate that mTORC1 regulates SREBP by controlling the nuclear entry of lipin 1, a phosphatidic acid phosphatase.

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At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mammalian cells
Journal	Cell
Year	2011
Peer reviewed	Yes
Record last updated	2026-08-22
Source	DOI 10.1016/j.cell.2011.06.034 · PMID 21816276 · Free full text (PMC3336367)

Extracted findings

Intervention	Genetic/pharmacologic (mTORC1/lipin1)
Target	mTORC1 / lipin1 / SREBP
Model	Mammalian cells
Effect	mTORC1 controls lipin1 nuclear entry to regulate the SREBP lipogenic transcription program

In the Atlas

Cite this paper

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Peterson, T. R., et al. (2011). mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell. https://doi.org/10.1016/j.cell.2011.06.034

@article{PET2011,
  author       = {Peterson, T. R. and Sabatini, D. M. and others},
  title        = {{mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway}},
  journal      = {Cell},
  year         = {2011},
  doi          = {10.1016/j.cell.2011.06.034},
  note         = {PMID: 21816276},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record PET2011) [Data set]. https://mtor-atlas.org/study/PET2011/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_PET2011,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record PET2011},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/PET2011/},
  doi          = {10.5281/zenodo.22059963}
}