mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway

Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM · 2011 · Cell · Atlas ID PET2011

What this study shows

mTORC1 controls lipin-1 nuclear localization to regulate SREBP and lipid synthesis.

Abstract

ShowHide

The nutrient- and growth factor-responsive kinase mTOR complex 1 (mTORC1) regulates many processes that control growth, including protein synthesis, autophagy, and lipogenesis. Through unknown mechanisms, mTORC1 promotes the function of SREBP, a master regulator of lipo- and sterolgenic gene transcription. Here, we demonstrate that mTORC1 regulates SREBP by controlling the nuclear entry of lipin 1, a phosphatidic acid phosphatase.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mammalian cells
Journal	Cell
Year	2011
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1016/j.cell.2011.06.034 · PMID 21816276 · Free full text (PMC3336367)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Genetic/pharmacologic (mTORC1/lipin1)
Target	mTORC1 / lipin1 / SREBP
Model	Mammalian cells
Effect	mTORC1 controls lipin1 nuclear entry to regulate the SREBP lipogenic transcription program

In the Atlas

Links in the pathway map

Supports mTORC1 activates SREBP1 / SREBP2
Supports SREBP1 / SREBP2 activates Lipid synthesis

Cite this paper

ShowHide

Peterson, T. R., Sengupta, S. S., Harris, T. E., Carmack, A. E., Kang, S. A., Balderas, E., Guertin, D. A., Madden, K. L., Carpenter, A. E., Finck, B. N., & Sabatini, D. M. (2011). mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell. https://doi.org/10.1016/j.cell.2011.06.034

@article{PET2011,
  author       = {Peterson, T. R. and Sengupta, S. S. and Harris, T. E. and Carmack, A. E. and Kang, S. A. and Balderas, E. and Guertin, D. A. and Madden, K. L. and Carpenter, A. E. and Finck, B. N. and Sabatini, D. M.},
  title        = {{mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway}},
  journal      = {Cell},
  year         = {2011},
  doi          = {10.1016/j.cell.2011.06.034},
  note         = {PMID: 21816276},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record PET2011) [Data set]. https://mtor-atlas.org/study/PET2011/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_PET2011,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record PET2011},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/PET2011/},
  doi          = {10.5281/zenodo.22059963}
}

Was this page useful?