Review of the mTOR network in metabolism and signalling crosstalk.
| Evidence tier | D Mechanistic / in vitro / review |
| Study type | Narrative Review |
| Model system | Review |
| Journal | Nature reviews. Molecular cell biology |
| Year | 2014 |
| Peer reviewed | Yes |
| Source | DOI 10.1038/nrm3757 · PMID 24556838 |
More than 20 years after its discovery, our understanding of target of rapamycin (TOR) signalling continues to grow. Recent global omics studies have revealed physiological roles of mammalian TOR (mTOR) in protein, nucleotide and lipid synthesis. Furthermore, emerging evidence provides new insight into the control of mTOR by other pathways such as Hippo, WNT and Notch signalling. Together, this progress has expanded the list of downstream effectors and upstream regulators of mTOR signalling.
| Intervention | Not applicable (review) |
| Target | mTOR network |
| Model | Review |
| Effect | Reviews mTOR crosstalk with Hippo/WNT/Notch and its roles in protein, nucleotide and lipid synthesis |