Making new contacts: the mTOR network in metabolism and signalling crosstalk

Shimobayashi M, Hall MN · 2014 · Nature reviews. Molecular cell biology · Atlas ID SHI2014

What this study shows

Review of the mTOR network in metabolism and signalling crosstalk.

Abstract

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More than 20 years after its discovery, our understanding of target of rapamycin (TOR) signalling continues to grow. Recent global omics studies have revealed physiological roles of mammalian TOR (mTOR) in protein, nucleotide and lipid synthesis. Furthermore, emerging evidence provides new insight into the control of mTOR by other pathways such as Hippo, WNT and Notch signalling. Together, this progress has expanded the list of downstream effectors and upstream regulators of mTOR signalling.

Read the full abstract on PubMed →

At a glance

Evidence type	R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study type	Narrative Review
Model system	Review
Journal	Nature reviews. Molecular cell biology
Year	2014
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1038/nrm3757 · PMID 24556838

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Not applicable (review)
Target	mTOR network
Model	Review
Effect	Reviews mTOR crosstalk with Hippo/WNT/Notch and its roles in protein, nucleotide and lipid synthesis

In the Atlas

Links in the pathway map

Supports SREBP1 / SREBP2 activates Lipid synthesis

Cite this paper

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Shimobayashi, M., & Hall, M. N. (2014). Making new contacts: the mTOR network in metabolism and signalling crosstalk. Nature reviews. Molecular cell biology. https://doi.org/10.1038/nrm3757

@article{SHI2014,
  author       = {Shimobayashi, M. and Hall, M. N.},
  title        = {{Making new contacts: the mTOR network in metabolism and signalling crosstalk}},
  journal      = {Nature reviews. Molecular cell biology},
  year         = {2014},
  doi          = {10.1038/nrm3757},
  note         = {PMID: 24556838},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record SHI2014) [Data set]. https://mtor-atlas.org/study/SHI2014/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_SHI2014,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record SHI2014},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/SHI2014/},
  doi          = {10.5281/zenodo.22059963}
}

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