Every study and every topic in the Atlas, as a plain index. 275 studies, 35 topics.
Autophagy (17) · Cellular senescence (3) · Muscle growth (3)
Alzheimer's disease (3) · Breast cancer (3) · Renal cell carcinoma (RCC) (3) · Tuberous sclerosis complex (3)
Rapamycin (36) · Everolimus (11) · Metformin (3) · Resveratrol (3)
mTOR (58) · Akt/PKB (10) · AMPK (8) · Rheb (8) · S6K1 (8) · TSC1/TSC2 (8) · 4E-BP1 (7) · Raptor (7) · PI3K (5) · Rag GTPases (5) · SLC38A9 (5) · ULK1 (5) · Rictor (3) · TFEB (3)
Lysosome (4)
Longevity (34) · Immune function (5) · Insulin resistance (4)
mTORC1 (73) · mTORC2 (14) · Ragulator (3)
Sorted by year, newest first. Each links to a page with the abstract, evidence tier, DOI and PMID.
Notoginsenoside R1 Alleviates Acetaminophen-Induced Liver Injury via MAPK/mTOR-Mediated Autophagy.
2026 · The American Journal of Chinese Medicine · C
Astragaloside IV Mitigates Tacrolimus-Induced Chronic Nephrotoxicity by Regulating the mTOR-TFEB-GADD45alpha Pathway
2026 · Journal of Agricultural and Food Chemistry · D
Molecular and metabolic dysregulation of lung cancer in developing anti-tumor activity by gambogic acid mediated mTOR signaling: in vitro and computational study.
2026 · 3 Biotech · D
Substrate recognition and transport mechanism of the human proton-coupled amino-acid transporter 1 (SLC36A1)
2026 · Nature Communications · D
Testosterone propionate maintains autophagic flux and mitochondrial integrity via regulation of the LC3B/p62/Beclin-1/mTOR axis in induced liver fibrosis.
2026 · Journal of Molecular Histology · C
Decoding the PI3K/Akt/mTOR-JAK/STAT signaling axis in multiple sclerosis: mechanistic crosstalk and therapeutic opportunities.
2026 · Immunologic research · D
Age-associated decline of Lamtor5 drives immunosenescence and systemic aging via cGAS-mediated paracrine inflammation.
2026 · Cell Death and Differentiation · C
Association of rapamycin treatment with the modulation of purine metabolism, reduced microglial inflammatory responses, improved mitochondrial energy metabolism, and alleviation of fatigue symptoms in ME/CFS subjects: pilot findings from phase-II observational study
2026 · Journal of Translational Medicine · B
Redox-sensitive mTOR-eIF4A signaling promotes selective P-glycoprotein translation.
2026 · Free radical biology & medicine · D
Biological limits of lifespan extension: evidence for a shift from pathway leverage to system-level buffering across species
2026 · Mechanisms of Ageing and Development · D
GPR143, a novel immunohistochemical marker for renal tumors with FLCN/TSC/MTOR-TFE alterations.
2026 · Virchows Archiv · D
Constitutive mTORC1 Activation in Skeletal Muscle Increases Inflammation but is not Sufficient to Impair Glucose Tolerance.
2026 · Function (Oxford, England) · C
ER-Lysosome Cholesterol Exchange Regulates Lysosomal Motility Through mTOR-Dependent LAMTOR1 Phosphorylation
2026 · bioRxiv (preprint) · —
SLC15A3-mediated dipeptide metabolism confers antimetabolite resistance in lymphoma via mTORC1 activation.
2026 · Journal of Clinical Investigation · C
Urolithin A activates mitophagy via the AMPK-mTOR axis and modulates the gut-ceramide axis to ameliorate cardiac remodeling in HFpEF
2026 · Experimental and Molecular Medicine · C
EVERolimus effectiveness after proGREssion on ENdocrine therapy plus CDK4/6 inhibitor for ER-positive/HER2-negative advanced breast cancer: EVERGREEN study
2026 · Breast Cancer Research and Treatment · B
Restriction of individual branched-chain amino acids has distinct effects on the development and progression of Alzheimer's disease in 3xTg mice
2026 · Advanced Science · C
LKB1/AMPK deficiency aggravates mitochondrial DNA leakage via mTOR-dependent mitophagy damage in liver injury sensitized by trichloroethylene.
2026 · Chemico-Biological Interactions · C
PIP4K2A Attenuates Cerebral Ischemia/Reperfusion Injury by Reducing the TRIB3-p62 Complex Burden and Modulating AKT/mTOR Signaling.
2026 · Translational stroke research · C
Rapamycin co-exposure fails to reduce cisplatin-induced damage in GC6-spg spermatogonial cell line.
2026 · Reproduction & Fertility · D
Spalt-related is an inhibitor of mTORC1-mediated growth activated by the integrated stress response
2026 · The EMBO Journal · C
The Bi-steric, mTORC1-Selective Inhibitor, RMC-5552, in Advanced Solid Tumors: A Phase 1 Trial
2025 · Clinical Cancer Research · B
Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results
2025 · Aging (Albany NY) · B
What is the clinical evidence to support off-label rapamycin therapy in healthy adults?
2025 · Aging (Albany NY) · D
mTORC1, the maestro of cell metabolism and growth
2025 · Genes & Development · D
mTORC1 activity oscillates throughout the cell cycle, promoting mitotic entry and differentially influencing autophagy induction
2024 · Cell Reports · D
Targeting ageing with rapamycin and its derivatives in humans: a systematic review
2024 · Lancet Healthy Longevity · A
Targeting mTOR restores tau-induced metabolic, mitochondrial, and cognitive deficits in a tauopathy mouse model
2024 · bioRxiv (preprint) · —
The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease
2023 · Nature reviews. Molecular cell biology · D
A bi-steric mTORC1-selective inhibitor overcomes drug resistance in breast cancer
2023 · Oncogene · C
mTOR substrate phosphorylation in growth control
2022 · Cell · D
Regulation and metabolic functions of mTORC1 and mTORC2
2021 · Physiological reviews · D
Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials
2021 · Lancet Healthy Longevity · B
Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction
2021 · Proceedings of the National Academy of Sciences of the United States of America · D
AIMTOR, a BRET biosensor for live imaging, reveals subcellular mTOR signaling and dysfunctions
2020 · BMC Biology · D
mTOR at the nexus of nutrition, growth, ageing and disease
2020 · Nature Reviews Molecular Cell Biology · D
A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dube syndrome
2020 · Nature · D
The 3.2-A resolution structure of human mTORC2
2020 · Science advances · D
Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex
2019 · Science · D
mTOR as a central hub of nutrient signalling and cell growth
2019 · Nature cell biology · D
Molecular logic of mTORC1 signalling as a metabolic rheostat
2019 · Nature metabolism · D
Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial
2019 · GeroScience · B
Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex
2019 · Cell · D
Architecture of human Rag GTPase heterodimers and their complex with mTORC1
2019 · Science · D
The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism
2019 · Nature reviews. Cancer · D
Structural basis for the docking of mTORC1 on the lysosomal surface
2019 · Science · D
A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort
2018 · Experimental Gerontology · B
TORC1 inhibition enhances immune function and reduces infections in the elderly
2018 · Science Translational Medicine · B
mTOR signalling and cellular metabolism are mutual determinants in cancer
2018 · Nature reviews. Cancer · D
Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state
2018 · Nature structural & molecular biology · D
Cryo-EM structure of human mTOR complex 2
2018 · Cell research · D
A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase-Ragulator lysosomal scaffold
2018 · Nature cell biology · D
Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes
2018 · Nature · D
Architecture of the human mTORC2 core complex
2018 · eLife · D
mTORC2 Promotes Tumorigenesis via Lipid Synthesis
2017 · Cancer cell · C
mTOR Signaling in Growth, Metabolism, and Disease
2017 · Cell · D
Twenty-five years of mTOR: Uncovering the link from nutrients to growth
2017 · Proceedings of the National Academy of Sciences of the United States of America · D
mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability
2017 · Cancer cell · D
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1
2017 · Nature · D
mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient
2017 · Cell · D
Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex
2017 · Molecular cell · D
Caloric restriction improves health and survival of rhesus monkeys
2017 · Nature Communications · C
Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2
2017 · Nature communications · D
The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway
2017 · Cell metabolism · D
SZT2 dictates GATOR control of mTORC1 signalling
2017 · Nature · D
A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs
2017 · GeroScience · C
Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex
2017 · Cell Metabolism · D
Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40
2017 · Nature · D
SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway
2017 · Science · D
Lysosomal recruitment of TSC2 is a universal response to cellular stress
2016 · Nature communications · D
mTOR Signaling Confers Resistance to Targeted Cancer Drugs
2016 · Trends in cancer · D
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging
2016 · Cell Metabolism · D
Mechanism of arginine sensing by CASTOR1 upstream of mTORC1
2016 · Nature · D
Safety of two-year caloric restriction in non-obese healthy individuals
2016 · Oncotarget · B
Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor
2016 · Nature · D
Tor forms a dimer through an N-terminal helical solenoid with a complex topology
2016 · Nature communications · D
Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice
2016 · eLife · C
The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
2016 · Cell · D
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
2016 · Science · D
Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot
2016 · Cell metabolism · D
Sestrin2 is a leucine sensor for the mTORC1 pathway
2015 · Science · D
Metabolism. Differential regulation of mTORC1 by leucine and glutamine
2015 · Science · D
Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system
2015 · Aging cell · C
PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex
2015 · Cancer discovery · D
mTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
2015 · Nature Cell Biology · D
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
2015 · Science · D
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
2015 · Nature · D
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
2015 · Science · D
Regulation of mTORC1 by PI3K signaling
2015 · Trends in cell biology · D
Architecture of human mTOR complex 1
2015 · Science · D
Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9
2015 · Molecular and cellular biology · D
mTOR inhibition improves immune function in the elderly
2014 · Science Translational Medicine · B
Mammalian target of rapamycin signaling in cardiac physiology and disease
2014 · Circulation research · D
The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice
2014 · Cell Metabolism · C
Acarbose, 17-alpha-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males
2014 · Aging Cell · C
Sestrins inhibit mTORC1 kinase activation through the GATOR complex
2014 · Cell reports · D
The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1
2014 · Cell reports · D
Making new contacts: the mTOR network in metabolism and signalling crosstalk
2014 · Nature reviews. Molecular cell biology · D
Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome
2014 · PloS one · C
Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib
2014 · Cancer discovery · B
A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity
2014 · Cancer discovery · D
Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls
2014 · Diabetes, Obesity and Metabolism · B
Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2
2014 · Cell · D
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome
2014 · Cell · D
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction
2014 · Aging cell · C
mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation
2013 · Cell metabolism · D
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1
2013 · Science · D
Where is mTOR and what is it doing there?
2013 · The Journal of cell biology · D
mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function
2013 · Nature · C
Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
2013 · Nature immunology · C
The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1
2013 · Molecular cell · D
mTOR kinase structure, mechanism and regulation
2013 · Nature · D
mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology
2013 · Proceedings of the National Academy of Sciences of the United States of America · D
A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1
2013 · Science · D
mTOR is a key modulator of ageing and age-related disease
2013 · Nature · D
Rapamycin extends murine lifespan but has limited effects on aging
2013 · The Journal of clinical investigation · C
Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression
2013 · Cell reports · C
Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis
2013 · Science · D
Late-life rapamycin treatment reverses age-related heart dysfunction
2013 · Aging Cell · C
mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6
2013 · Nature cell biology · D
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output
2013 · Nature cell biology · D
Overexpression of Atg5 in mice activates autophagy and extends lifespan
2013 · Nature Communications · C
Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases
2013 · The Journal of cell biology · D
Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1
2013 · Science signaling · D
The translational landscape of mTOR signalling steers cancer initiation and metastasis
2012 · Nature · D
Regulation and function of mTOR signalling in T cell fate decisions
2012 · Nature reviews. Immunology · D
Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival
2012 · Nature · C
Genome sequencing identifies a basis for everolimus sensitivity
2012 · Science · B
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1
2012 · Cell · D
Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice
2012 · J Gerontol A Biol Sci Med Sci · C
MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
2012 · Autophagy · D
Chronic inhibition of mTOR by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice
2012 · Neuroscience · C
mTOR signaling in growth control and disease
2012 · Cell · D
Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer (BOLERO-2)
2012 · New England Journal of Medicine · B
The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis
2012 · Science signaling · D
TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1
2012 · Molecular cell · D
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
2012 · Science · D
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
2012 · The EMBO journal · D
Rapamycin slows aging in mice
2012 · Aging Cell · C
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO
2012 · Cell metabolism · C
A unifying model for mTORC1-mediated regulation of mRNA translation
2012 · Nature · D
SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling
2012 · Molecular cell · D
Glutaminolysis activates Rag-mTORC1 signaling
2012 · Molecular cell · D
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
2012 · Cell · D
Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop
2011 · Autophagy · D
Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size
2011 · Molecular cell · D
mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling
2011 · Cancer discovery · D
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
2011 · Nature immunology · C
Efficacy and safety of sirolimus in lymphangioleiomyomatosis (MILES)
2011 · New England Journal of Medicine · B
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling
2011 · Science · D
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice
2011 · J Gerontol A Biol Sci Med Sci · C
Everolimus for advanced pancreatic neuroendocrine tumors (RADIANT-3)
2011 · New England Journal of Medicine · B
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase
2011 · Science · D
Regulation of immune responses by mTOR
2011 · Annual review of immunology · D
Activation of mTORC2 by association with the ribosome
2011 · Cell · D
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway
2011 · Cell · D
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
2011 · Immunity · C
TFEB links autophagy to lysosomal biogenesis
2011 · Science · D
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling
2011 · Science · D
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
2011 · Nature Cell Biology · D
Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate
2011 · The Journal of biological chemistry · D
Extending healthy life span--from yeast to humans
2010 · Science · D
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
2010 · Science · D
Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor
2010 · Nature medicine · D
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster
2010 · Cell Metabolism · C
Molecular interplay between mTOR, amyloid-beta, and Tau: effects on cognitive impairments
2010 · Journal of Biological Chemistry · C
Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E
2010 · Cancer cell · D
Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis
2010 · New England Journal of Medicine · B
Termination of autophagy and reformation of lysosomes regulated by mTOR
2010 · Nature · D
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease
2010 · PLoS ONE · C
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
2010 · Cell · D
mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists
2010 · Science · C
mTOR: from growth signal integration to cancer, diabetes and ageing
2010 · Nature reviews. Molecular cell biology · D
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
2010 · Nature · D
Molecular mechanisms of mTOR-mediated translational control
2009 · Nature reviews. Molecular cell biology · D
mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging
2009 · Cell stem cell · C
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2
2009 · PLoS Biology · D
mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice
2009 · Cancer cell · C
Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)
2009 · The Biochemical journal · D
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
2009 · Journal of Biological Chemistry · D
Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis
2009 · Journal of Physiology · B
Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice
2009 · The Journal of neuroscience · C
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
2009 · Science · C
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
2009 · Immunity · D
AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity
2009 · Cancer research · D
mTOR regulates memory CD8 T-cell differentiation
2009 · Nature · C
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
2009 · Molecular Biology of the Cell · D
ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy
2009 · The Journal of biological chemistry · D
Rapamycin decelerates cellular senescence
2009 · Cell Cycle · D
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
2009 · Nature · C
4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila
2009 · Cell · C
mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
2009 · Science signaling · C
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
2009 · Cell · D
AMPK phosphorylation of raptor mediates a metabolic checkpoint
2008 · Molecular Cell · D
Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy
2008 · Cell metabolism · C
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
2008 · Science · D
Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial
2008 · Lancet · B
Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration
2008 · Cell metabolism · C
Regulation of TORC1 by Rag GTPases in nutrient response
2008 · Nature cell biology · D
Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis
2008 · Nature medicine · C
Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis
2008 · The New England journal of medicine · B
The TSC-mTOR signaling pathway regulates the innate inflammatory response
2008 · Immunity · D
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
2008 · The Journal of clinical investigation · D
Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function
2008 · The Journal of neuroscience · C
TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
2008 · Journal of Experimental Medicine · C
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
2008 · The Biochemical journal · D
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
2008 · Cell metabolism · D
Defining the role of mTOR in cancer
2007 · Cancer Cell · D
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex
2007 · Nature · D
The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1
2007 · The Journal of biological chemistry · D
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
2007 · Molecular Cell · D
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
2007 · New England Journal of Medicine · B
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
2007 · Nature cell biology · D
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
2006 · Cell · D
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
2006 · Molecular Cell · D
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
2006 · Cancer research · D
S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth
2006 · Science · D
mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
2006 · Current biology : CB · D
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
2006 · Genes & development · D
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
2006 · Developmental Cell · D
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
2006 · Cell · D
Extension of chronological life span in yeast by decreased TOR pathway signaling
2006 · Genes & development · C
TOR signaling in growth and metabolism
2006 · Cell · D
Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition
2006 · Cell Cycle · D
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
2005 · Science · C
Rheb binds and regulates the mTOR kinase
2005 · Current biology : CB · D
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
2005 · Science · D
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
2004 · Nature · C
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
2004 · Current Biology · D
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
2004 · Nature cell biology · D
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
2004 · Nature medicine · C
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
2004 · Nature Genetics · C
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
2004 · Current Biology · C
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
2004 · Genes & development · D
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
2003 · Genes & development · D
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
2003 · Molecular Cell · D
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
2003 · Molecular cell · D
Rheb promotes cell growth as a component of the insulin/TOR signalling network
2003 · Nature cell biology · D
TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function
2003 · Current biology : CB · D
TSC2 mediates cellular energy response to control cell growth and survival
2003 · Cell · D
Genetics: influence of TOR kinase on lifespan in C. elegans
2003 · Nature · C
Autophagy genes are essential for dauer development and life-span extension in C. elegans
2003 · Science · C
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
2003 · Current Biology · D
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
2003 · Nature cell biology · D
The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif
2003 · The Journal of biological chemistry · D
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
2002 · Nature Cell Biology · D
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
2002 · Cell · D
The phosphoinositide 3-kinase pathway
2002 · Science · D
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
2002 · Molecular cell · D
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
2002 · Genes & development · D
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
2002 · Cell · D
Role of AMP-activated protein kinase in mechanism of metformin action
2001 · J Clin Invest · D
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
2001 · Nature cell biology · C
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways
2001 · Nature Cell Biology · D
Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study
2000 · Lancet · B
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism
1999 · Genes & development · D
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
1998 · Proceedings of the National Academy of Sciences of the United States of America · D
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
1998 · The Journal of biological chemistry · D
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin
1997 · Science · D
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1996 · Nature · C
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1996 · Science · D
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1995 · The Journal of biological chemistry · D
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1994 · Cell · D
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1994 · Nature · D
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1992 · Cell · D
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1992 · Nature · D
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1992 · Science · D
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