Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

Stocker H, Radimerski T, Schindelholz B, Wittwer F, Belawat P, Daram P, Breuer S, Thomas G, Hafen E · 2003 · Nature cell biology · Atlas ID STO2003

What this study shows

Rheb is an essential regulator of S6K controlling cell growth downstream of TSC in Drosophila.

Abstract

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Understanding the mechanisms through which multicellular organisms regulate cell, organ and body growth is of relevance to developmental biology and to research on growth-related diseases such as cancer. Here we describe a new effector in growth control, the small GTPase Rheb (Ras homologue enriched in brain). Mutations in the Drosophila melanogaster Rheb gene were isolated as growth-inhibitors, whereas overexpression of Rheb promoted cell growth.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Drosophila) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Drosophila
Journal	Nature cell biology
Year	2003
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1038/ncb995 · PMID 12766775

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Genetic (Rheb mutants/overexpression)
Target	Rheb / S6K / TOR
Model	Drosophila
Effect	Rheb is an essential regulator of S6K controlling cell growth in Drosophila

In the Atlas

Cite this paper

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Stocker, H., Radimerski, T., Schindelholz, B., Wittwer, F., Belawat, P., Daram, P., Breuer, S., Thomas, G., & Hafen, E. (2003). Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nature cell biology. https://doi.org/10.1038/ncb995

@article{STO2003,
  author       = {Stocker, H. and Radimerski, T. and Schindelholz, B. and Wittwer, F. and Belawat, P. and Daram, P. and Breuer, S. and Thomas, G. and Hafen, E.},
  title        = {{Rheb is an essential regulator of S6K in controlling cell growth in Drosophila}},
  journal      = {Nature cell biology},
  year         = {2003},
  doi          = {10.1038/ncb995},
  note         = {PMID: 12766775},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record STO2003) [Data set]. https://mtor-atlas.org/study/STO2003/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_STO2003,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record STO2003},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/STO2003/},
  doi          = {10.5281/zenodo.22059963}
}

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