Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

Understanding the mechanisms through which multicellular organisms regulate cell, organ and body growth is of relevance to developmental biology and to research on growth-related diseases such as cancer. Here we describe a new effector in growth control, the small GTPase Rheb (Ras homologue enriched in brain). Mutations in the Drosophila melanogaster Rheb gene were isolated as growth-inhibitors, whereas overexpression of Rheb promoted cell growth.

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Stocker, H., et al. (2003). Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nature cell biology. https://doi.org/10.1038/ncb995

@article{STO2003,
  author       = {Stocker, H. and Hafen, E. and others},
  title        = {{Rheb is an essential regulator of S6K in controlling cell growth in Drosophila}},
  journal      = {Nature cell biology},
  year         = {2003},
  doi          = {10.1038/ncb995},
  note         = {PMID: 12766775},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record STO2003) [Data set]. https://mtor-atlas.org/study/STO2003/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_STO2003,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record STO2003},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/STO2003/},
  doi          = {10.5281/zenodo.22059963}
}