The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

The kinase mTOR has emerged as an important regulator of the differentiation of helper T cells. Here we demonstrate that differentiation into the T(H)1 and T(H)17 subsets of helper T cells was selectively regulated by signaling from mTOR complex 1 (mTORC1) that was dependent on the small GTPase Rheb. Rheb-deficient T cells failed to generate T(H)1 and T(H)17 responses in vitro and in vivo and did not induce classical experimental autoimmune encephalomyelitis (EAE). However, they retained their ability to become T(H)2 cells.

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Delgoffe, G. M., et al. (2011). The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nature immunology. https://doi.org/10.1038/ni.2005

@article{DEL2011,
  author       = {Delgoffe, G. M. and Powell, J. D. and others},
  title        = {{The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2}},
  journal      = {Nature immunology},
  year         = {2011},
  doi          = {10.1038/ni.2005},
  note         = {PMID: 21358638},
}

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The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record DEL2011) [Data set]. https://mtor-atlas.org/study/DEL2011/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_DEL2011,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record DEL2011},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/DEL2011/},
  doi          = {10.5281/zenodo.22059963}
}