Jonathan D. Powell
Showed that T cells lacking mTOR become regulatory T cells instead of effector cells, and that mTORC1 and mTORC2 each steer a different type of helper T cell
Fellow, Calico Life Sciences · 20 years at Johns Hopkins University (Bloomberg-Kimmel Institute for Cancer Immunotherapy) · MD, PhD, Emory University School of Medicine
Profile, Calico Life Sciences (South San Francisco, California, USA) ↗
Portrait: Calico Life Sciences
Jonathan Powell spent two decades as a physician-scientist at Johns Hopkins, where his lab established mTOR as a central integrator of the metabolic and environmental signals that tell an immune cell what to become.
His group showed that mTOR differentially regulates effector and regulatory T cell lineage commitment, and that selective activation of mTORC1 versus mTORC2 signalling steers helper T cell differentiation — work that contributed to the field of immunometabolism and pointed to mTOR as a target for both cancer immunotherapy and autoimmune disease. He is now a Fellow at Calico Life Sciences, where his lab works on immunology, immunometabolism, cancer and aging.
The timeline below follows Powell's contributions gathered in this Atlas.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2009 | M | The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment DEL2009 Shows mTOR differentially regulates effector and regulatory T cell lineage commitment. |
| 2011 | A | The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2 DEL2011 Shows mTOR regulates helper T cell differentiation through the selective activation of mTORC1 versus mTORC2 signalling. |
| 2011 | R | Regulation of immune responses by mTOR POW2011 Reviews how mTOR regulates immune responses. |
| 2015 | A | mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation POL2015 Senior author: shows that mTORC1 and mTORC2 separately shape CD8 T-cell fate in mice, with constant mTORC1 driving terminal effectors and loss of mTORC2 favouring memory cells. |
Co-authors in the Atlas 5
People with a profile here who share at least one study with Jonathan D. Powell.
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- Greg M. Delgoffe 3 shared studies Showed as a graduate student in Jonathan Powell's lab that T cells lacking mTOR become regulatory rather than effector T cells, and that mTORC1 and mTORC2 steer different helper-T-cell fates
- Adam T. Waickman 2 shared studies Immunologist who trained in Jonathan Powell's mTOR and T cell lab at Johns Hopkins and now studies human immune responses to dengue virus at SUNY Upstate Medical University
- Kristen N. Pollizzi 2 shared studies Immunologist trained in Jonathan Powell's lab at Johns Hopkins who used gene deletions in mice to show how the two mTOR complexes push killer T cells toward effector or memory fates
- Maureen R. Horton 2 shared studies Pulmonary physician-scientist who studies immune mechanisms of lung inflammation and fibrosis
- Sara C. Kozma Studies the S6K/mTOR pathway and how it controls cell growth, ribosome production, diabetes and cancer, including mTOR signalling in liver cancer.
Every researcher with a profile →
On the programme
Meetings in the Atlas calendar where Jonathan D. Powell is listed among the speakers or organisers.
- upcoming Keystone Symposia: Tumor and Host Metabolism – Integrating Molecular, Cellular, and Systemic Interactions 2027 ↗ 7–10 Mar 2027 ·
Princeton, NJ, USA · ★★ Add to calendar:
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