Regulation of immune responses by mTOR

Powell JD, Pollizzi KN, Heikamp EB, Horton MR · 2011 · Annual review of immunology · Atlas ID POW2011

What this study shows

Review of mTOR as an integrator of immune-cell metabolism and differentiation.

Abstract

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mTOR is an evolutionarily conserved serine/threonine kinase that plays a central role in integrating environmental cues in the form of growth factors, amino acids, and energy. In the study of the immune system, mTOR is emerging as a critical regulator of immune function because of its role in sensing and integrating cues from the immune microenvironment. With the greater appreciation of cellular metabolism as an important regulator of immune cell function, mTOR is proving to be a vital link between immune function and metabolism.

Read the full abstract on PubMed →

At a glance

Evidence type	R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study type	Narrative Review
Model system	Review
Journal	Annual review of immunology
Year	2011
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1146/annurev-immunol-020711-075024 · PMID 22136167 · Free full text (PMC3616892)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Not applicable (review)
Target	mTOR (immune)
Model	Review
Effect	Reviews mTOR as a central regulator of immune responses

In the Atlas

Cite this paper

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Powell, J. D., Pollizzi, K. N., Heikamp, E. B., & Horton, M. R. (2011). Regulation of immune responses by mTOR. Annual review of immunology. https://doi.org/10.1146/annurev-immunol-020711-075024

@article{POW2011,
  author       = {Powell, J. D. and Pollizzi, K. N. and Heikamp, E. B. and Horton, M. R.},
  title        = {{Regulation of immune responses by mTOR}},
  journal      = {Annual review of immunology},
  year         = {2011},
  doi          = {10.1146/annurev-immunol-020711-075024},
  note         = {PMID: 22136167},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record POW2011) [Data set]. https://mtor-atlas.org/study/POW2011/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_POW2011,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record POW2011},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/POW2011/},
  doi          = {10.5281/zenodo.22059963}
}

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