Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2

TOR complex 1 (TORC1) is a potent anabolic regulator of cellular growth and metabolism. When cells have sufficient amino acids, TORC1 is active due to its lysosomal localization mediated via the Rag GTPases. Upon amino acid removal, the Rag GTPases release TORC1, causing it to become cytoplasmic and inactive. We show here that, upon amino acid removal, the Rag GTPases also recruit TSC2 to the lysosome, where it can act on Rheb. Only when both the Rag GTPases and Rheb are inactive is TORC1 fully released from the lysosome.

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Demetriades, C., et al. (2014). Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2. Cell. https://doi.org/10.1016/j.cell.2014.01.024

@article{DEM2014,
  author       = {Demetriades, C. and Teleman, A. A. and others},
  title        = {{Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2}},
  journal      = {Cell},
  year         = {2014},
  doi          = {10.1016/j.cell.2014.01.024},
  note         = {PMID: 24529380},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record DEM2014) [Data set]. https://mtor-atlas.org/study/DEM2014/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_DEM2014,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record DEM2014},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/DEM2014/},
  doi          = {10.5281/zenodo.22059963}
}