Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2

Demetriades C, Doumpas N, Teleman AA · 2014 · Cell · Atlas ID DEM2014

What this study shows

Amino-acid starvation recruits TSC2 to the lysosome to inhibit Rheb and TORC1.

Abstract

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TOR complex 1 (TORC1) is a potent anabolic regulator of cellular growth and metabolism. When cells have sufficient amino acids, TORC1 is active due to its lysosomal localization mediated via the Rag GTPases. Upon amino acid removal, the Rag GTPases release TORC1, causing it to become cytoplasmic and inactive. We show here that, upon amino acid removal, the Rag GTPases also recruit TSC2 to the lysosome, where it can act on Rheb. Only when both the Rag GTPases and Rheb are inactive is TORC1 fully released from the lysosome.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mammalian cells
Journal	Cell
Year	2014
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1016/j.cell.2014.01.024 · PMID 24529380 · Free full text (PMC4346203)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Biochemical/genetic (Rag / TSC2)
Target	TORC1 / Rag GTPases / TSC2
Model	Mammalian cells
Effect	Upon amino-acid starvation the Rag GTPases recruit TSC2 to the lysosome to inactivate TORC1

In the Atlas

Links in the pathway map

Supports TSC1/TSC2 inhibits mTORC1
Supports Rag GTPases recruits TSC1/TSC2

Cite this paper

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Demetriades, C., Doumpas, N., & Teleman, A. A. (2014). Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2. Cell. https://doi.org/10.1016/j.cell.2014.01.024

@article{DEM2014,
  author       = {Demetriades, C. and Doumpas, N. and Teleman, A. A.},
  title        = {{Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2}},
  journal      = {Cell},
  year         = {2014},
  doi          = {10.1016/j.cell.2014.01.024},
  note         = {PMID: 24529380},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record DEM2014) [Data set]. https://mtor-atlas.org/study/DEM2014/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_DEM2014,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record DEM2014},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/DEM2014/},
  doi          = {10.5281/zenodo.22059963}
}

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