Aurelio A. Teleman
Pioneered Drosophila genetics to dissect TOR-driven growth signaling, then showed lysosomal TSC2 relocation is a universal brake on mTORC1
AB Biochemistry, Harvard (Richard Losick, 1998) · McKinsey & Co. (2001–2002) · PhD, EMBL & Imperial College London (Stephen M. Cohen, 2004) · DKFZ Junior Group Leader (2007) → Division Head (since 2012); EMBO Member (2020)
Division of Signal Transduction in Cancer and Metabolism, DKFZ, Heidelberg ↗
Portrait: German Cancer Research Center (DKFZ)
As corresponding author, guided Demetriades to the TSC2/lysosome discoveries (DEM2014, DEM2016) — showing mTORC1's starvation shutdown depends on TSC2 acting at the lysosome, then generalizing to many stress types.
Trained as biochemist at Harvard, PhD with Stephen Cohen (fly growth signaling), briefly a McKinsey consultant. ERC Starting/Consolidator/Advanced grants.
Milestones in the Atlas
| Year | Evidence | Study |
|---|---|---|
| 2014 | M | Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2 DEM2014 Senior author: amino-acid starvation recruits TSC2 to the lysosome to inhibit Rheb and mTORC1. |
| 2016 | M | Lysosomal recruitment of TSC2 is a universal response to cellular stress DEM2016 Senior author: lysosomal TSC2 recruitment triggered by many cellular stresses, a general damage-control mechanism. |