Bernadette Carroll

First author of the study showing why mTORC1 stays switched on in senescent cells, and co-author on G3BP–TSC and senescence-mitophagy work; her own lab studies how nutrient sensing breaks down in ageing cells.

Senior Lecturer in Molecular Cell Biology, University of Bristol · Vice-Chancellor's Fellow, then Wellcome Trust/Royal Society Sir Henry Dale Fellow, Bristol · postdoc with Viktor Korolchuk, Newcastle University · PhD, Imperial College London

Carroll Lab, School of Biochemistry and Biomedical Sciences, University of Bristol (Bristol, England, United Kingdom) ↗ ORCID0000-0001-5673-9371 ↗

Portrait: University of Bristol

As a postdoc in Viktor Korolchuk's lab in Newcastle, Carroll was first author of the 2017 paper showing that mTORC1 in senescent human fibroblasts no longer responds to amino acid or serum withdrawal because of defects upstream of the kinase (CAR2017). She is a co-author on the G3BP–TSC lysosome study (PRE2021) and on the 2024 paper linking loss of basal mitophagy to cellular ageing and to the anti-senescence effect of rapamycin (KEL2024).

Carroll did her PhD at Imperial College London and her postdoc at Newcastle University. She set up her lab at the University of Bristol as a Vice-Chancellor's Fellow and then a Sir Henry Dale Fellow; the lab asks why mTORC1 becomes unresponsive to nutrients in senescence.

Milestones in the Atlas

A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.

Co-authors in the Atlas

People with a profile here who share at least one study with Bernadette Carroll.

• Viktor I. Korolchuk 3 shared studies Showed that where lysosomes sit inside the cell tunes mTORC1 activity to nutrient supply. His Newcastle lab found that senescent cells can no longer switch mTORC1 off when nutrients or growth factors are withdrawn, and studies how autophagy and mitophagy decline with age
• Thomas von Zglinicki 2 shared studies Cell-senescence researcher who co-authored the Newcastle studies on stuck-on mTORC1 in senescent cells and on loss of basal mitophagy as a driver of cellular ageing.
• Julian R. Sampson Clinical geneticist who led the consortium that identified the TSC2 gene and led trials of mTOR inhibitors in tuberous sclerosis, including the TRON trial of everolimus for cognition.
• Kathrin Thedieck Senior author of three Atlas studies that treat mTOR signalling as a dynamic network: TSC-independent mTORC2 activation, concurrent AMPK and mTOR activation by amino acids, and G3BP tethering of TSC to lysosomes.
• Mirja Tamara Prentzell First author of the study showing that G3BP proteins anchor the TSC complex to lysosomes, a physical brake on mTORC1; earlier co-author on the dynamic insulin–mTOR network model.
• Ralf Baumeister Head of the Freiburg department that hosted the Thedieck group during the mTOR network modelling work; co-author on the dynamic mTOR model and the G3BP–TSC study.
• Satomi Miwa Mitochondrial biologist who contributed to Newcastle studies on rapamycin in NF-κB-driven ageing mice and on basal mitophagy as a brake on cellular senescence.

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