Thomas von Zglinicki
Cell-senescence researcher who co-authored the Newcastle studies on stuck-on mTORC1 in senescent cells and on loss of basal mitophagy as a driver of cellular ageing.
Professor of Cellular Gerontology, Biosciences Institute, Newcastle University · founding member of ageing biology research at Newcastle and former Scientific Director of the Newcastle University Institute for Ageing (per BSRA, 2017)
Portrait: British Society for Research on Ageing (BSRA)
Von Zglinicki is a co-author on the study showing that mTORC1 stays active in senescent fibroblasts because nutrient and growth-factor sensing fail upstream (CAR2017). He is also a co-author on the 2024 paper showing that basal mitophagy shuts down in senescent and aged cells, and that restoring it is needed for rapamycin's anti-senescence effect (KEL2024).
He is Professor of Cellular Gerontology at Newcastle University. His earlier work showed that oxidative stress speeds up telomere shortening, and he received the Lord Cohen of Birkenhead Medal of the British Society for Research on Ageing in 2017.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2017 | M | Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing CAR2017 Co-author: senescent cells keep mTORC1 active through defects in amino acid and growth-factor sensing. |
| 2024 | M | Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule KEL2024 Co-author: suppressed basal mitophagy drives senescence; reversible with a p62-targeting molecule. |
Co-authors in the Atlas
People with a profile here who share at least one study with Thomas von Zglinicki.
- Bernadette Carroll 2 shared studies First author of the study showing why mTORC1 stays switched on in senescent cells, and co-author on G3BP–TSC and senescence-mitophagy work; her own lab studies how nutrient sensing breaks down in ageing cells.
- Viktor I. Korolchuk 2 shared studies Showed that where lysosomes sit inside the cell tunes mTORC1 activity to nutrient supply. His Newcastle lab found that senescent cells can no longer switch mTORC1 off when nutrients or growth factors are withdrawn, and studies how autophagy and mitophagy decline with age
- Satomi Miwa Mitochondrial biologist who contributed to Newcastle studies on rapamycin in NF-κB-driven ageing mice and on basal mitophagy as a brake on cellular senescence.
Every researcher with a profile →
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