Satomi Miwa
Mitochondrial biologist who contributed to Newcastle studies on rapamycin in NF-κB-driven ageing mice and on basal mitophagy as a brake on cellular senescence.
Lecturer in Translational Biology of Ageing, Biosciences Institute, Newcastle University · PhD in Biochemistry, University of Cambridge (Martin Brand lab)
Biosciences Institute, Newcastle University (Newcastle upon Tyne, England, United Kingdom) ↗ Lab lineagetrained under Martin D. Brand →
Portrait: Alliance for Healthy Aging
Miwa is a co-author on the 2018 study in which rapamycin improved healthspan but not inflammaging or lifespan in nfkb1 knockout mice (COR2018). She is also a co-author on the 2024 paper showing that basal mitophagy falls in senescent and aged human cells and is needed for the anti-senescence effect of rapamycin (KEL2024).
She trained first as a sport scientist, then did a PhD in biochemistry with Martin Brand at Cambridge on mitochondrial reactive oxygen species and ageing. At Newcastle she studies mitochondrial function in ageing and senescent-cell therapies.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2018 | A | Rapamycin improves healthspan but not inflammaging in nfκb1(-/-) mice. COR2018 Co-author: rapamycin improved frailty and memory in nfkb1 mice without reducing inflammaging. |
| 2024 | M | Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule KEL2024 Co-author: loss of basal mitophagy drives senescence; mitophagy needed for rapamycin's effect. |
Co-authors in the Atlas
People with a profile here who share at least one study with Satomi Miwa.
- Viktor I. Korolchuk 2 shared studies Showed that where lysosomes sit inside the cell tunes mTORC1 activity to nutrient supply. His Newcastle lab found that senescent cells can no longer switch mTORC1 off when nutrients or growth factors are withdrawn, and studies how autophagy and mitophagy decline with age
- Bernadette Carroll First author of the study showing why mTORC1 stays switched on in senescent cells, and co-author on G3BP–TSC and senescence-mitophagy work; her own lab studies how nutrient sensing breaks down in ageing cells.
- João F. Passos Studies how senescent cells, mitochondria and telomeres contribute to ageing and age-related disease.
- Thomas von Zglinicki Cell-senescence researcher who co-authored the Newcastle studies on stuck-on mTORC1 in senescent cells and on loss of basal mitophagy as a driver of cellular ageing.
Every researcher with a profile →
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