João F. Passos
Studies how senescent cells, mitochondria and telomeres contribute to ageing and age-related disease.
Professor of Physiology, Mayo Clinic · Newcastle University Institute for Ageing (affiliation on the 2018 paper)
Portrait: Mayo Clinic
João Passos is a professor of physiology at Mayo Clinic in Rochester, Minnesota, where he leads the Cell and Molecular Aging Laboratory. His page says he studies the role of senescent cells in ageing and age-related disease, with a focus on mitochondria and telomeres. He earned his PhD at Newcastle University.
In the 2018 Aging Cell paper in the Atlas, he was the last author, with the work done at the Newcastle University Institute for Ageing. The team gave rapamycin to mice lacking the gene nfkb1, which age fast and show chronic inflammation, and asked whether it would help.
Rapamycin improved healthspan in these mice, but it did not lower the chronic low-level inflammation of ageing, often called inflammaging. The result separates the two effects, which matters for deciding how rapamycin might act as an ageing treatment.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2018 | A | Rapamycin improves healthspan but not inflammaging in nfκb1(-/-) mice. COR2018 Last author of the study showing that rapamycin improved healthspan in nfkb1 mutant mice without reducing inflammaging. |
Co-authors in the Atlas
People with a profile here who share at least one study with João F. Passos.
- Satomi Miwa Mitochondrial biologist who contributed to Newcastle studies on rapamycin in NF-κB-driven ageing mice and on basal mitophagy as a brake on cellular senescence.
- Viktor I. Korolchuk Showed that where lysosomes sit inside the cell tunes mTORC1 activity to nutrient supply. His Newcastle lab found that senescent cells can no longer switch mTORC1 off when nutrients or growth factors are withdrawn, and studies how autophagy and mitophagy decline with age
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