Mirja Tamara Prentzell
First author of the study showing that G3BP proteins anchor the TSC complex to lysosomes, a physical brake on mTORC1; earlier co-author on the dynamic insulin–mTOR network model.
Deputy Division Head, Metabolic Crosstalk in Cancer, DKFZ Heidelberg · earlier work with the Thedieck group (Freiburg) on mTOR signalling
Opitz Lab (Division of Metabolic Crosstalk in Cancer), German Cancer Research Center DKFZ (Heidelberg, Germany) ↗ ORCID0000-0002-9659-9825 ↗
Portrait: German Cancer Research Center (DKFZ)
Prentzell is first author of the 2021 Cell paper showing that G3BP1 and G3BP2, known as stress-granule proteins, also hold the TSC complex at the lysosome and so restrain mTORC1 (PRE2021). In the DKFZ press release she described the G3BP proteins as an anchor that lets the TSC complex bind to lysosomes. Nine years earlier she was a co-author on the data-fitted dynamic model of the insulin–mTOR network from the Freiburg and Newcastle groups (DAL2012).
She is listed as Deputy Division Head in Christiane Opitz's division Metabolic Crosstalk in Cancer at the German Cancer Research Center (DKFZ) in Heidelberg, and took part in the EU MESI-STRAT consortium on metabolic signalling in breast cancer.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2012 | M | A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation DAL2012 Co-author on the dynamic network model showing mTORC2 activation is independent of TSC1-TSC2. |
| 2021 | M | G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling PRE2021 First author: G3BP1/2 tether the TSC complex to lysosomes; their loss makes mTORC1 over-responsive to amino acids and insulin. |
Co-authors in the Atlas
People with a profile here who share at least one study with Mirja Tamara Prentzell.
- Kathrin Thedieck 2 shared studies Senior author of three Atlas studies that treat mTOR signalling as a dynamic network: TSC-independent mTORC2 activation, concurrent AMPK and mTOR activation by amino acids, and G3BP tethering of TSC to lysosomes.
- Ralf Baumeister 2 shared studies Head of the Freiburg department that hosted the Thedieck group during the mTOR network modelling work; co-author on the dynamic mTOR model and the G3BP–TSC study.
- Annika G. Sonntag Experimental researcher in the Thedieck group who contributed cell data to the dynamic mTOR network model and the AMPK–mTOR amino acid study.
- Bernadette Carroll First author of the study showing why mTORC1 stays switched on in senescent cells, and co-author on G3BP–TSC and senescence-mitophagy work; her own lab studies how nutrient sensing breaks down in ageing cells.
- Daryl P. Shanley Systems biologist of ageing whose Newcastle modelling group built, with the Thedieck lab, the dynamic models of mTOR signalling in the Atlas.
- Julian R. Sampson Clinical geneticist who led the consortium that identified the TSC2 gene and led trials of mTOR inhibitors in tuberous sclerosis, including the TRON trial of everolimus for cognition.
- Piero Dalle Pezze First author of two Atlas modelling studies: the dynamic insulin–mTOR network model (TSC-independent mTORC2) and the systems study of concurrent AMPK and mTOR activation by amino acids.
- Viktor I. Korolchuk Showed that where lysosomes sit inside the cell tunes mTORC1 activity to nutrient supply. His Newcastle lab found that senescent cells can no longer switch mTORC1 off when nutrients or growth factors are withdrawn, and studies how autophagy and mitophagy decline with age
Every researcher with a profile →
Thank you. Your answer was counted anonymously.
Thank you. That helps us know which pages have been read by someone who knows the work.
Thank you. We will check it and correct the page.