Ralf Baumeister
Head of the Freiburg department that hosted the Thedieck group during the mTOR network modelling work; co-author on the dynamic mTOR model and the G3BP–TSC study.
Professor of Bioinformatics and Molecular Genetics, University of Freiburg (since 2003) · Professor of Metabolic Biochemistry, LMU Munich (2000–2003) · postdoc with Gary Ruvkun, Harvard Medical School (1992–1995) · PhD, University of Erlangen (1992)
Baumeister Lab, Bioinformatics and Molecular Genetics, Institute of Biology III, University of Freiburg (Freiburg, Germany) ↗ Lab lineagetrained under Gary Ruvkun →
Portrait: University of Freiburg
Baumeister co-authored the 2012 dynamic network model of insulin–mTOR signalling, built while Kathrin Thedieck led a group in his Freiburg department (DAL2012). He is also a co-author on the 2021 study showing that G3BP proteins tether the TSC complex to lysosomes, which used zebrafish and other models across a European consortium (PRE2021).
He trained at the University of Erlangen (PhD 1992) and did a postdoc with Gary Ruvkun at Harvard Medical School. After group-leader and professor posts in Munich he moved to Freiburg in 2003, where his lab uses the nematode C. elegans to study disease genes, mTORC2 and autophagy; he was founding director of Freiburg's Center for Biological Systems Analysis (ZBSA).
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2012 | M | A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation DAL2012 Co-author and host department head: dynamic insulin–mTOR model showing mTORC2 is not regulated by TSC1-TSC2. |
| 2021 | M | G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling PRE2021 Co-author on the finding that G3BPs anchor the TSC complex at lysosomes and suppress mTORC1. |
Co-authors in the Atlas
People with a profile here who share at least one study with Ralf Baumeister.
- Kathrin Thedieck 2 shared studies Senior author of three Atlas studies that treat mTOR signalling as a dynamic network: TSC-independent mTORC2 activation, concurrent AMPK and mTOR activation by amino acids, and G3BP tethering of TSC to lysosomes.
- Mirja Tamara Prentzell 2 shared studies First author of the study showing that G3BP proteins anchor the TSC complex to lysosomes, a physical brake on mTORC1; earlier co-author on the dynamic insulin–mTOR network model.
- Annika G. Sonntag Experimental researcher in the Thedieck group who contributed cell data to the dynamic mTOR network model and the AMPK–mTOR amino acid study.
- Bernadette Carroll First author of the study showing why mTORC1 stays switched on in senescent cells, and co-author on G3BP–TSC and senescence-mitophagy work; her own lab studies how nutrient sensing breaks down in ageing cells.
- Daryl P. Shanley Systems biologist of ageing whose Newcastle modelling group built, with the Thedieck lab, the dynamic models of mTOR signalling in the Atlas.
- Julian R. Sampson Clinical geneticist who led the consortium that identified the TSC2 gene and led trials of mTOR inhibitors in tuberous sclerosis, including the TRON trial of everolimus for cognition.
- Piero Dalle Pezze First author of two Atlas modelling studies: the dynamic insulin–mTOR network model (TSC-independent mTORC2) and the systems study of concurrent AMPK and mTOR activation by amino acids.
- Viktor I. Korolchuk Showed that where lysosomes sit inside the cell tunes mTORC1 activity to nutrient supply. His Newcastle lab found that senescent cells can no longer switch mTORC1 off when nutrients or growth factors are withdrawn, and studies how autophagy and mitophagy decline with age
Every researcher with a profile →
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