Lysosomal recruitment of TSC2 is a universal response to cellular stress

Demetriades C, Plescher M, Teleman AA · 2016 · Nature communications · Atlas ID DEM2016

What this study shows

Lysosomal recruitment of TSC2 is a universal response to cellular stress that inhibits mTORC1.

Abstract

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mTORC1 promotes cell growth and is therefore inactivated upon unfavourable growth conditions. Signalling pathways downstream of most cellular stresses converge on TSC1/2, which serves as an integration point that inhibits mTORC1. The TSC1/2 complex was shown to translocate to lysosomes to inactivate mTORC1 in response to two stresses: amino-acid starvation and growth factor removal. Whether other stresses also regulate TSC2 localization is not known. How TSC2 localization responds to combinations of stresses and other stimuli is also unknown.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mammalian cells
Journal	Nature communications
Year	2016
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1038/ncomms10662 · PMID 26868506 · Free full text (PMC4754342)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Various cellular stresses (amino-acid/growth-factor withdrawal, etc.) – mechanistic
Target	TSC2 / mTORC1
Model	Mammalian cells
Effect	Diverse stresses relocate TSC2 to the lysosome → inhibit mTORC1 (a universal response)

In the Atlas

Links in the pathway map

Supports Energy & cellular stress recruits TSC1/TSC2

Learn the biology

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Cite this paper

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Demetriades, C., Plescher, M., & Teleman, A. A. (2016). Lysosomal recruitment of TSC2 is a universal response to cellular stress. Nature communications. https://doi.org/10.1038/ncomms10662

@article{DEM2016,
  author       = {Demetriades, C. and Plescher, M. and Teleman, A. A.},
  title        = {{Lysosomal recruitment of TSC2 is a universal response to cellular stress}},
  journal      = {Nature communications},
  year         = {2016},
  doi          = {10.1038/ncomms10662},
  note         = {PMID: 26868506},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record DEM2016) [Data set]. https://mtor-atlas.org/study/DEM2016/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_DEM2016,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record DEM2016},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/DEM2016/},
  doi          = {10.5281/zenodo.22059963}
}

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