Oliver's mTOR Atlas Evidence Platform
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Lysosomal recruitment of TSC2 is a universal response to cellular stress

Demetriades C, Teleman AA et al. · 2016 · Nature communications · Atlas ID DEM2016

What this study shows

Lysosomal recruitment of TSC2 is a universal response to cellular stress that inhibits mTORC1.

Abstract

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mTORC1 promotes cell growth and is therefore inactivated upon unfavourable growth conditions. Signalling pathways downstream of most cellular stresses converge on TSC1/2, which serves as an integration point that inhibits mTORC1. The TSC1/2 complex was shown to translocate to lysosomes to inactivate mTORC1 in response to two stresses: amino-acid starvation and growth factor removal. Whether other stresses also regulate TSC2 localization is not known. How TSC2 localization responds to combinations of stresses and other stimuli is also unknown.

Read the full abstract on PubMed →

At a glance

Evidence type M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type5 - Mechanistic / In Vitro
Model systemMammalian cells
JournalNature communications
Year2016
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1038/ncomms10662 · PMID 26868506 · Free full text (PMC4754342)

Extracted findings

InterventionVarious cellular stresses (amino-acid/growth-factor withdrawal, etc.) – mechanistic
TargetTSC2 / mTORC1
ModelMammalian cells
EffectDiverse stresses relocate TSC2 to the lysosome → inhibit mTORC1 (a universal response)

In the Atlas

Related topics

LysosomeEnergy & cellular stress

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Cite this paper

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Demetriades, C., et al. (2016). Lysosomal recruitment of TSC2 is a universal response to cellular stress. Nature communications. https://doi.org/10.1038/ncomms10662

@article{DEM2016,
  author       = {Demetriades, C. and Teleman, A. A. and others},
  title        = {{Lysosomal recruitment of TSC2 is a universal response to cellular stress}},
  journal      = {Nature communications},
  year         = {2016},
  doi          = {10.1038/ncomms10662},
  note         = {PMID: 26868506},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record DEM2016) [Data set]. https://mtor-atlas.org/study/DEM2016/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_DEM2016,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record DEM2016},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/DEM2016/},
  doi          = {10.5281/zenodo.22059963}
}