Oliver's mTOR Atlas Evidence Platform
Reading level
Mode

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome

Menon S, Manning BD et al. · 2014 · Cell · Atlas ID MEN2014

What this study shows

Spatial control of the TSC complex integrates insulin and nutrient inputs at the lysosome.

Abstract

ShowHide

mTORC1 promotes cell growth in response to nutrients and growth factors. Insulin activates mTORC1 through the PI3K-Akt pathway, which inhibits the TSC1-TSC2-TBC1D7 complex (the TSC complex) to turn on Rheb, an essential activator of mTORC1. However, the mechanistic basis of how this pathway integrates with nutrient-sensing pathways is unknown. We demonstrate that insulin stimulates acute dissociation of the TSC complex from the lysosomal surface, where subpopulations of Rheb and mTORC1 reside.

Read the full abstract on PubMed →

At a glance

Evidence type M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type5 - Mechanistic / In Vitro
Model systemMammalian cells
JournalCell
Year2014
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1016/j.cell.2013.11.049 · PMID 24529379 · Free full text (PMC4030681)

Extracted findings

InterventionGenetic/biochemical (TSC complex/Rheb)
TargetTSC complex / Rheb / mTORC1
ModelMammalian cells
EffectInsulin drives lysosomal dissociation of the TSC complex, integrating insulin and nutrient regulation of mTORC1

In the Atlas

Related topics

Energy & cellular stress

More studies on this topic

Learn the biology

Want to understand the biology behind this study? → The TSC Complex — Where the Inputs Meet

Cite this paper

ShowHide 
Menon, S., et al. (2014). Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. Cell. https://doi.org/10.1016/j.cell.2013.11.049

@article{MEN2014,
  author       = {Menon, S. and Manning, B. D. and others},
  title        = {{Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome}},
  journal      = {Cell},
  year         = {2014},
  doi          = {10.1016/j.cell.2013.11.049},
  note         = {PMID: 24529379},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record MEN2014) [Data set]. https://mtor-atlas.org/study/MEN2014/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_MEN2014,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record MEN2014},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/MEN2014/},
  doi          = {10.5281/zenodo.22059963}
}