Pathway link STRESS-TSC

Energy & cellular stress – TSC1/TSC2

Energy & cellular stress recruits TSC1/TSC2.

Different kinds of stress all do the same physical thing: they drag TSC2 over to the lysosome, right next to Rheb. Moving it there is the switch, not making more of it.

Many different stresses do the same physical thing: they drag TSC2 onto the lysosome, right where Rheb is. That relocation, not a change in TSC2 amount, is the switch.

The conditions it holds under

Mammalian cell studies (DEM2016, MEN2014). Relocation of TSC2 to the lysosome is shown in cultured cells under several stresses; not tested in tissue or in people.

Time it takes

minutes

Step

direct (one molecule acts on the other)

Measured in

mammalian cells

Where in the cell

lysosome

Reaches people?

plausible in people, not shown directly

How settled

emerging, few independent studies

Studies behind it

Points the other way

No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.

Who has checked this

Checked by

No researcher outside the project has checked this link yet.

Curator sign-off

Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.

Curated by

Oliver Barton, with AI help for drafting; see how links are checked.

“How settled” describes how far researchers in the field agree. It is not the same as the sign-off above, which only says whether a named curator has checked this page.

If this link rests on your own work: a click on “This looks right” below, or a short note through “Report an error”, helps us more than anything else on this page.

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