Oliver's mTOR Atlas Evidence Platform
Reading level
Mode

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

Bar-Peled L, Sabatini DM et al. · 2012 · Cell · Atlas ID BAR2012

What this study shows

Ragulator is the guanine-nucleotide exchange factor activating the Rag GTPases on the lysosome.

Abstract

ShowHide

The mTOR Complex 1 (mTORC1) pathway regulates cell growth in response to numerous cues, including amino acids, which promote mTORC1 translocation to the lysosomal surface, its site of activation. The heterodimeric RagA/B-RagC/D GTPases, the Ragulator complex that tethers the Rags to the lysosome, and the v-ATPase form a signaling system that is necessary for amino acid sensing by mTORC1. Amino acids stimulate the binding of guanosine triphosphate to RagA and RagB but the factors that regulate Rag nucleotide loading are unknown.

Read the full abstract on PubMed →

At a glance

Evidence type M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type5 - Mechanistic / In Vitro
Model systemMammalian cells
JournalCell
Year2012
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1016/j.cell.2012.07.032 · PMID 22980980 · Free full text (PMC3517996)

Extracted findings

InterventionBiochemical/genetic (Ragulator)
TargetRagulator / Rag GTPases / mTORC1
ModelMammalian cells
EffectRagulator is a GEF for RagA/B, activating the Rags to signal amino-acid levels to mTORC1 at the lysosome

In the Atlas

Related topics

Lysosome

More studies on this topic

Learn the biology

Want to understand the biology behind this study? → The Lysosome as a Signalling Platform

Cite this paper

ShowHide 
Bar-Peled, L., et al. (2012). Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell. https://doi.org/10.1016/j.cell.2012.07.032

@article{BAR2012,
  author       = {Bar-Peled, L. and Sabatini, D. M. and others},
  title        = {{Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1}},
  journal      = {Cell},
  year         = {2012},
  doi          = {10.1016/j.cell.2012.07.032},
  note         = {PMID: 22980980},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record BAR2012) [Data set]. https://mtor-atlas.org/study/BAR2012/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_BAR2012,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record BAR2012},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/BAR2012/},
  doi          = {10.5281/zenodo.22059963}
}