Where is mTOR and what is it doing there?

Target of rapamycin (TOR) forms two conserved, structurally distinct kinase complexes termed TOR complex 1 (TORC1) and TORC2. Each complex phosphorylates a different set of substrates to regulate cell growth. In mammals, mTOR is stimulated by nutrients and growth factors and inhibited by stress to ensure that cells grow only during favorable conditions. Studies in different organisms have reported localization of TOR to several distinct subcellular compartments. Notably, the finding that mTORC1 is localized to the lysosome has significantly enhanced our understanding of mTORC1 regulation.

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Betz, C., et al. (2013). Where is mTOR and what is it doing there?. The Journal of cell biology. https://doi.org/10.1083/jcb.201306041

@article{BETZ2013,
  author       = {Betz, C. and Hall, M. N. and others},
  title        = {{Where is mTOR and what is it doing there?}},
  journal      = {The Journal of cell biology},
  year         = {2013},
  doi          = {10.1083/jcb.201306041},
  note         = {PMID: 24385483},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record BETZ2013) [Data set]. https://mtor-atlas.org/study/BETZ2013/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_BETZ2013,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record BETZ2013},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/BETZ2013/},
  doi          = {10.5281/zenodo.22059963}
}