Where is mTOR and what is it doing there?

Betz C, Hall MN · 2013 · The Journal of cell biology · Atlas ID BETZ2013

What this study shows

Review of where mTOR localizes and its compartmentalized functions.

Abstract

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Target of rapamycin (TOR) forms two conserved, structurally distinct kinase complexes termed TOR complex 1 (TORC1) and TORC2. Each complex phosphorylates a different set of substrates to regulate cell growth. In mammals, mTOR is stimulated by nutrients and growth factors and inhibited by stress to ensure that cells grow only during favorable conditions. Studies in different organisms have reported localization of TOR to several distinct subcellular compartments. Notably, the finding that mTORC1 is localized to the lysosome has significantly enhanced our understanding of mTORC1 regulation.

Read the full abstract on PubMed →

At a glance

Evidence type	R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study type	Narrative Review
Model system	Review
Journal	The Journal of cell biology
Year	2013
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1083/jcb.201306041 · PMID 24385483 · Free full text (PMC3840941)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Not applicable (review)
Target	TORC1 / TORC2 (subcellular localization)
Model	Review
Effect	Reviews where the mTOR complexes localize and what they do at each site

In the Atlas

Cite this paper

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Betz, C., & Hall, M. N. (2013). Where is mTOR and what is it doing there?. The Journal of cell biology. https://doi.org/10.1083/jcb.201306041

@article{BETZ2013,
  author       = {Betz, C. and Hall, M. N.},
  title        = {{Where is mTOR and what is it doing there?}},
  journal      = {The Journal of cell biology},
  year         = {2013},
  doi          = {10.1083/jcb.201306041},
  note         = {PMID: 24385483},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record BETZ2013) [Data set]. https://mtor-atlas.org/study/BETZ2013/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_BETZ2013,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record BETZ2013},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/BETZ2013/},
  doi          = {10.5281/zenodo.22059963}
}

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