Charles Betz
Traced mTORC2 to a specific address inside the cell — the mitochondria-ER contact site
Head of International Relations, Directorate of Health, Luxembourg (since 2022) · Luxinnovation (2017–2022) · research staff, vascular-biology groups, Biozentrum · PhD & postdoc, Michael Hall lab, Biozentrum
Michael N. Hall Lab, Biozentrum, University of Basel (where these studies were done) (Basel, Switzerland) ↗ Lab lineagetrained under Michael N. Hall → ORCID0000-0002-9837-6916 ↗
Portrait: Biozentrum, University of Basel
Showed (BET2013) mTORC2 concentrates at mitochondria-associated ER membranes (MAM), phosphorylating tether proteins via Akt; disrupting mTORC2 broke the ER-mitochondria tether, damaging membrane potential/ATP/calcium handling. Co-authored the widely cited review (BETZ2013) arguing mTOR's subcellular address is a regulatory layer in its own right.
PhD and postdoc in Hall's lab (later a co-author of a 2018 Nature paper on LHPP as a tumor suppressor). Moved into vascular biology, then public-health administration.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2012 | A | Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c HAG2012 Co-author: liver-specific loss of mTORC2 blocks feeding-induced glycolysis and lipogenesis, acting mainly through Akt (mice). |
| 2013 | R | Where is mTOR and what is it doing there? BETZ2013 Review arguing mTOR's subcellular location, not just activity, is a core regulatory layer. |
| 2013 | M | mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology BET2013 mTORC2-Akt signaling concentrates at mitochondria-ER contact sites, maintaining the tether required for normal mitochondrial function. |
Co-authors in the Atlas 6
People with a profile here who share at least one study with Charles Betz.
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- Michael N. Hall 3 shared studies Discovered TOR in yeast in 1991 and established it as a central controller of cell growth that responds to nutrients. His lab later showed that TOR works in two distinct complexes, TORC1 and TORC2, only one of which is blocked by rapamycin
- Asami Hagiwara First author of a 2012 mouse study from Michael Hall's lab showing that liver mTORC2 tells the liver that the animal has eaten, by switching on sugar breakdown and fat production
- Daniele Stracka Co-author of two studies from Michael Hall's laboratory in Basel that placed mTORC2, the second mTOR complex, at the ribosome and at contact sites between the endoplasmic reticulum and mitochondria
- Marion Cornu Physiologist from Michael Hall's Basel lab who showed in mice that mTORC1 in the liver controls body temperature, movement and fat metabolism through the hormone FGF21
- Markus A. Rüegg Neurobiologist at the Biozentrum of the University of Basel who studies how muscles and the nerve connections that drive them develop, age and fail, including the role of mTOR signalling in muscle.
- Nadine Cybulski Cell biologist from Michael Hall's Basel lab who showed that mTORC2 in fat tissue helps control how big the whole body grows
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