mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology

Betz C, Hall MN et al. · 2013 · Proceedings of the National Academy of Sciences of the United States of America · Atlas ID BET2013

What this study shows

mTORC2-Akt signalling localizes to mitochondria-associated ER membranes to regulate mitochondrial function.

Abstract

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The target of rapamycin (TOR) is a highly conserved protein kinase and a central controller of growth. Mammalian TOR complex 2 (mTORC2) regulates AGC kinase family members and is implicated in various disorders, including cancer and diabetes. Here we report that mTORC2 is localized to the endoplasmic reticulum (ER) subcompartment termed mitochondria-associated ER membrane (MAM). mTORC2 localization to MAM was growth factor-stimulated, and mTORC2 at MAM interacted with the IP3 receptor (IP3R)-Grp75-voltage-dependent anion-selective channel 1 ER-mitochondrial tethering complex.

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At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mammalian cells
Journal	Proceedings of the National Academy of Sciences of the United States of America
Year	2013
Peer reviewed	Yes
Record last updated	2026-08-22
Source	DOI 10.1073/pnas.1302455110 · PMID 23852728 · Free full text (PMC3732980)

Extracted findings

Intervention	Biochemical/genetic (mTORC2)
Target	mTORC2 / Akt / MAM
Model	Mammalian cells
Effect	mTORC2-Akt localizes to mitochondria-associated ER membranes (MAM) to regulate mitochondrial physiology

Cite this paper

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Betz, C., et al. (2013). mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.1302455110

@article{BET2013,
  author       = {Betz, C. and Hall, M. N. and others},
  title        = {{mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology}},
  journal      = {Proceedings of the National Academy of Sciences of the United States of America},
  year         = {2013},
  doi          = {10.1073/pnas.1302455110},
  note         = {PMID: 23852728},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record BET2013) [Data set]. https://mtor-atlas.org/study/BET2013/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_BET2013,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record BET2013},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/BET2013/},
  doi          = {10.5281/zenodo.22059963}
}