Peter Gollwitzer
First author of the 'Rag dimer code' study showing that the four Rag GTPase paralogues are not interchangeable: RagC/D sets substrate choice and RagA/B sets the response to amino acid withdrawal.
Postdoc, Frezza Lab, CECAD, University of Cologne (since late 2022) · PhD, University of Cologne / MPI for Biology of Ageing (supervisor Constantinos Demetriades; thesis ‘Role of the Rag GTPases in Amino Acid sensing and mTORC1 signaling’, defended 2022)
Frezza Lab, CECAD Cluster of Excellence, University of Cologne (Cologne, North Rhine-Westphalia, Germany) ↗ Lab lineagetrained under Constantinos Demetriades →
Portrait: Frezza Lab, CECAD, University of Cologne
His PhD project produced the finding that Rag GTPase dimers differ in function: only dimers containing RagD fully restore phosphorylation of TFEB and TFE3, and RagB-containing dimers keep mTORC1 at the lysosome during amino acid withdrawal (GOL2022). He also co-authored the malonyl-CoA study (NIC2023) and the work separating lysosomal and cytoplasmic mTORC1 (FER2024).
He did his doctorate in the Demetriades lab at the MPI for Biology of Ageing in Cologne, with the oral exam in September 2022. Since late 2022 he has been a postdoc in Christian Frezza's lab at CECAD, University of Cologne, where he studies how mitochondrial dysfunction feeds into cell signalling, currently through the integrated stress response. Before Cologne he trained at RWTH Aachen and spent time in David Ron's lab at the Cambridge Institute for Medical Research.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2022 | M | A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids GOL2022 First author: RagC/D determines substrate specificity and RagA/B the response to amino acid removal. |
| 2023 | M | Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor NIC2023 Co-author on malonyl-CoA as an endogenous ATP-competitive mTORC1 inhibitor. |
| 2024 | M | Spatial and functional separation of mTORC1 signalling in response to different amino acid sources FER2024 Co-author on the spatial separation of lysosomal and cytoplasmic mTORC1 signalling. |
Co-authors in the Atlas
People with a profile here who share at least one study with Peter Gollwitzer.
- Julian Nüchel 2 shared studies Co-author on two Demetriades-lab mTORC1 papers from Cologne: the spatial split of mTORC1 signalling by amino acid source and malonyl-CoA as a direct mTORC1 inhibitor.
- Sabine Wilhelm 2 shared studies Co-author on two Demetriades-lab studies of amino acid sensing by mTORC1: the Rag GTPase dimer code and the spatial split of mTORC1 signalling.
- Stephanie A. Fernandes 2 shared studies First author of the study showing that lysosomal and cytoplasmic pools of mTORC1 respond to different amino acid sources and phosphorylate different substrates.
- Claudio De Virgilio Yeast geneticist whose lab found the EGO/Rag GTPase complex that activates TORC1 and showed that the SEACIT complex (Iml1–Npr2–Npr3) switches TORC1 off by acting as a GAP for the Rag GTPase Gtr1.
- Jiyoung Pan PhD student who co-authored the 2024 study showing that mTORC1 does different jobs at the lysosome and away from it, and first author of a 2026 review on why mTORC1 is better seen as a substrate-selective kinase than an on/off switch
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