Oliver's mTOR Atlas Evidence Platform
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mTOR inhibition improves immune function in the elderly

Mannick JB et al. · 2014 · Science Translational Medicine · Atlas ID MAN2014

What this study shows

Low-dose everolimus improved influenza vaccine response by ~20% and reduced PD-1 expression on T lymphocytes.

Abstract

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Inhibition of the mammalian target of rapamycin (mTOR) pathway extends life span in all species studied to date, and in mice delays the onset of age-related diseases and comorbidities. However, it is unknown if mTOR inhibition affects aging or its consequences in humans. To begin to assess the effects of mTOR inhibition on human aging-related conditions, we evaluated whether the mTOR inhibitor RAD001 ameliorated immunosenescence (the decline in immune function during aging) in elderly volunteers, as assessed by their response to influenza vaccination.

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At a glance

Evidence type H Human study Marked H because it is direct evidence from a human clinical trial or human cohort; the code names the kind of study, not its quality -- a small, well-run trial is still H.
Study type2 - Human Clinical Trial
Model systemHumans, RCT, older adults
JournalScience Translational Medicine
Year2014
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1126/scitranslmed.3009892 · PMID 25540326

Extracted findings

InterventionEverolimus (RAD001), low dose
TargetmTORC1
ModelHuman – elderly adults, RCT
EffectImproved influenza vaccine response (~20%) and reduced PD-1 expression on T cells

In the Atlas

Related topics

EverolimusImmune function

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Cite this paper

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Mannick, J. B., et al. (2014). mTOR inhibition improves immune function in the elderly. Science Translational Medicine. https://doi.org/10.1126/scitranslmed.3009892

@article{MAN2014,
  author       = {Mannick, J. B. and others},
  title        = {{mTOR inhibition improves immune function in the elderly}},
  journal      = {Science Translational Medicine},
  year         = {2014},
  doi          = {10.1126/scitranslmed.3009892},
  note         = {PMID: 25540326},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record MAN2014) [Data set]. https://mtor-atlas.org/study/MAN2014/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_MAN2014,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record MAN2014},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/MAN2014/},
  doi          = {10.5281/zenodo.22059963}
}