IGF2BP3-Mediated m6A Modification of OLR1 mRNA Promotes Immune Evasion in CRC via the PI3K/AKT/mTOR Pathway

Chen W · 2026 · Journal of Immunotherapy · Atlas ID CHEN2026B

What this study shows

IGF2BP3 stabilizes OLR1 via m6A RNA modification, activating PI3K/AKT/mTOR signaling which suppresses CD8+ T cell anti-tumor activity and drives immune evasion in colorectal cancer.

Abstract

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OLR1 was upregulated in colorectal cancer (CRC) and negatively associated with CD8+ T-cell infiltration. Knockdown of OLR1 significantly enhanced the antitumor function of CD8+ T cells. Mechanistically, IGF2BP3 stabilized OLR1 mRNA in an m6A modification-dependent manner, thereby activating the PI3K/AKT/mTOR pathway to inhibit the antitumor activity of CD8+ T cells and promote immune evasion in CRC.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: CRC cell lines (human); TCGA dataset) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	CRC cell lines (human); TCGA dataset
Journal	Journal of Immunotherapy
Year	2026
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1097/CJI.0000000000000613 · PMID 42592954

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	OLR1 knockdown; IGF2BP3 modulation
Target	PI3K/AKT/mTOR pathway; OLR1; IGF2BP3; m6A RNA modification
Model	Human
Effect	m6A-stabilized OLR1 activates PI3K/AKT/mTOR to suppress CD8+ T cell function and enable CRC immune evasion; OLR1 knockdown restores T cell anti-tumor activity

In the Atlas

Cite this paper

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Chen, W. (2026). IGF2BP3-Mediated m6A Modification of OLR1 mRNA Promotes Immune Evasion in CRC via the PI3K/AKT/mTOR Pathway. Journal of Immunotherapy. https://doi.org/10.1097/CJI.0000000000000613

@article{CHEN2026B,
  author       = {Chen, W.},
  title        = {{IGF2BP3-Mediated m6A Modification of OLR1 mRNA Promotes Immune Evasion in CRC via the PI3K/AKT/mTOR Pathway}},
  journal      = {Journal of Immunotherapy},
  year         = {2026},
  doi          = {10.1097/CJI.0000000000000613},
  note         = {PMID: 42592954},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record CHEN2026B) [Data set]. https://mtor-atlas.org/study/CHEN2026B/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_CHEN2026B,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record CHEN2026B},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/CHEN2026B/},
  doi          = {10.5281/zenodo.22059963}
}

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