Review establishing PI3K as a central signaling hub controlling cell survival, metabolism, and growth downstream of growth-factor receptors and upstream of Akt and mTOR.
| Evidence tier | D Mechanistic / in vitro / review |
| Study type | Narrative Review |
| Model system | Review article |
| Journal | Science |
| Year | 2002 |
| Peer reviewed | Yes |
| Source | DOI 10.1126/science.296.5573.1655 · PMID 12040186 |
Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation of various signaling components. The role of phosphoinositide 3-kinase (PI3K), which catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate, in cell survival pathways; the regulation of gene expression and cell metabolism; and cytoskeletal rearrangements are highlighted. The PI3K pathway is implicated in human diseases including diabetes and cancer, and understanding the intricacies of this pathway may provide new avenues for therapuetic intervention.
| Intervention | Not applicable (review) |
| Target | PI3K / PIP3 (upstream of Akt-mTOR) |
| Model | Review |
| Effect | Reviews the PI3K pathway in cell survival, metabolism, gene expression and cytoskeletal control |