Oliver's mTOR Atlas Evidence Platform
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The phosphoinositide 3-kinase pathway

Cantley LC · 2002 · Science · Atlas ID CAN2002

What this study shows

Review establishing PI3K as a central signaling hub controlling cell survival, metabolism, and growth downstream of growth-factor receptors and upstream of Akt and mTOR.

Abstract

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Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation of various signaling components. The role of phosphoinositide 3-kinase (PI3K), which catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate, in cell survival pathways; the regulation of gene expression and cell metabolism; and cytoskeletal rearrangements are highlighted. The PI3K pathway is implicated in human diseases including diabetes and cancer, and understanding the intricacies of this pathway may provide new avenues for therapuetic intervention.

Read the full abstract on PubMed →

At a glance

Evidence type R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study typeNarrative Review
Model systemReview article
JournalScience
Year2002
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1126/science.296.5573.1655 · PMID 12040186

Extracted findings

InterventionNot applicable (review)
TargetPI3K / PIP3 (upstream of Akt-mTOR)
ModelReview
EffectReviews the PI3K pathway in cell survival, metabolism, gene expression and cytoskeletal control

In the Atlas

Related topics

Akt/PKBPI3K

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Learn the biology

Want to understand the biology behind this study? → Growth Factor Signalling

Cite this paper

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Cantley, L. C. (2002). The phosphoinositide 3-kinase pathway. Science. https://doi.org/10.1126/science.296.5573.1655

@article{CAN2002,
  author       = {Cantley, L. C.},
  title        = {{The phosphoinositide 3-kinase pathway}},
  journal      = {Science},
  year         = {2002},
  doi          = {10.1126/science.296.5573.1655},
  note         = {PMID: 12040186},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record CAN2002) [Data set]. https://mtor-atlas.org/study/CAN2002/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_CAN2002,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record CAN2002},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/CAN2002/},
  doi          = {10.5281/zenodo.22059963}
}