Decoding the PI3K/Akt/mTOR-JAK/STAT signaling axis in multiple sclerosis: mechanistic crosstalk and therapeutic opportunities.

Banerjee C, Singh RK, Choudhary D, Khan MN, Maurya PK, Khan Z et al. · 2026 · Immunologic research · Atlas ID BANERJEE2026

What this study shows

Review mapping the mechanistic crosstalk between PI3K/Akt/mTOR and JAK/STAT pathways in MS neuroinflammation, identifying dual-pathway mTOR targeting as a therapeutic opportunity to reduce immune dysregulation and demyelination.

Abstract

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Multiple Sclerosis (MS) is a chronic immune-mediated neurodegenerative disorder characterized by demyelination, axonal injury, and progressive neurological dysfunction. Emerging evidence identifies PI3K/Akt/mTOR and JAK/STAT pathways as interconnected regulators of neuroinflammation and immune dysregulation in MS.

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At a glance

Evidence type	R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study type	Narrative Review
Model system	Review
Journal	Immunologic research
Year	2026
Peer reviewed	Yes
Record last updated	2026-08-22
Source	DOI 10.1007/s12026-026-09808-9

Extracted findings

Intervention	mTOR inhibitors (proposed therapeutic)
Target	PI3K/Akt/mTOR-JAK/STAT axis
Model	N/A (review)
Effect	PI3K/Akt/mTOR-JAK/STAT crosstalk drives neuroinflammation in MS; mTOR inhibition proposed as treatment

In the Atlas

Cite this paper

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Banerjee, C., et al. (2026). Decoding the PI3K/Akt/mTOR-JAK/STAT signaling axis in multiple sclerosis: mechanistic crosstalk and therapeutic opportunities. Immunologic research. https://doi.org/10.1007/s12026-026-09808-9

@article{BANERJEE2026,
  author       = {Banerjee, C. and Singh, R. K. and Choudhary, D. and Khan, M. N. and Maurya, P. K. and Khan, Z. and others},
  title        = {{Decoding the PI3K/Akt/mTOR-JAK/STAT signaling axis in multiple sclerosis: mechanistic crosstalk and therapeutic opportunities}},
  journal      = {Immunologic research},
  year         = {2026},
  doi          = {10.1007/s12026-026-09808-9},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record BANERJEE2026) [Data set]. https://mtor-atlas.org/study/BANERJEE2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_BANERJEE2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record BANERJEE2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/BANERJEE2026/},
  doi          = {10.5281/zenodo.22059963}
}