Decoding the PI3K/Akt/mTOR-JAK/STAT signaling axis in multiple sclerosis: mechanistic crosstalk and therapeutic opportunities.

Banerjee C, Singh RK, Choudhary D, Khan MN, Maurya PK, Khan Z, Mehan S, Samant R, Tongra M · 2026 · Immunologic research · Atlas ID BANERJEE2026

What this study shows

Review mapping the mechanistic crosstalk between PI3K/Akt/mTOR and JAK/STAT pathways in MS neuroinflammation, identifying dual-pathway mTOR targeting as a therapeutic opportunity to reduce immune dysregulation and demyelination.

Abstract

ShowHide

Multiple Sclerosis (MS) is a chronic immune-mediated neurodegenerative disorder characterized by demyelination, axonal injury, and progressive neurological dysfunction. Emerging evidence identifies PI3K/Akt/mTOR and JAK/STAT pathways as interconnected regulators of neuroinflammation and immune dysregulation in MS.

Read the full abstract on PubMed →

At a glance

Evidence type	R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study type	Narrative Review
Model system	Review
Journal	Immunologic research
Year	2026
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1007/s12026-026-09808-9 · PMID 42467315

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	mTOR inhibitors (proposed therapeutic)
Target	PI3K/Akt/mTOR-JAK/STAT axis
Model	N/A (review)
Effect	PI3K/Akt/mTOR-JAK/STAT crosstalk drives neuroinflammation in MS; mTOR inhibition proposed as treatment

In the Atlas

Cite this paper

ShowHide

Banerjee, C., Singh, R. K., Choudhary, D., Khan, M. N., Maurya, P. K., Khan, Z., Mehan, S., Samant, R., & Tongra, M. (2026). Decoding the PI3K/Akt/mTOR-JAK/STAT signaling axis in multiple sclerosis: mechanistic crosstalk and therapeutic opportunities. Immunologic research. https://doi.org/10.1007/s12026-026-09808-9

@article{BANERJEE2026,
  author       = {Banerjee, C. and Singh, R. K. and Choudhary, D. and Khan, M. N. and Maurya, P. K. and Khan, Z. and Mehan, S. and Samant, R. and Tongra, M.},
  title        = {{Decoding the PI3K/Akt/mTOR-JAK/STAT signaling axis in multiple sclerosis: mechanistic crosstalk and therapeutic opportunities}},
  journal      = {Immunologic research},
  year         = {2026},
  doi          = {10.1007/s12026-026-09808-9},
  note         = {PMID: 42467315},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record BANERJEE2026) [Data set]. https://mtor-atlas.org/study/BANERJEE2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_BANERJEE2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record BANERJEE2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/BANERJEE2026/},
  doi          = {10.5281/zenodo.22059963}
}

Was this page useful?