Oliver's mTOR Atlas Evidence Platform
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Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways

Rommel C, Bodine SC et al. · 2001 · Nature Cell Biology · Atlas ID ROM2001

What this study shows

Shows IGF-1 drives muscle fiber hypertrophy specifically through the Akt-mTOR pathway, establishing mTORC1 as a central node for muscle growth signaling.

Abstract

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Skeletal muscle is composed of multinucleated fibres, formed after the differentiation and fusion of myoblast precursors. Skeletal muscle atrophy and hypertrophy refer to changes in the diameter of these pre-existing muscle fibres. The prevention of atrophy would provide an obvious clinical benefit; insulin-like growth factor 1 (IGF-1) is a promising anti-atrophy agent because of its ability to promote hypertrophy.

Read the full abstract on PubMed →

At a glance

Evidence type M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Cultured muscle cells (mouse)) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type5 - Mechanistic / In Vitro
Model systemCultured muscle cells (mouse)
JournalNature Cell Biology
Year2001
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1038/ncb1101-1009 · PMID 11715022

Extracted findings

InterventionIGF-1
TargetPI3K/Akt/mTOR & Akt/GSK3
ModelCultured muscle cells (mouse)
EffectIGF-1 drives skeletal myotube hypertrophy via PI3K/Akt/mTOR and PI3K/Akt/GSK3 pathways

In the Atlas

Related topics

Muscle growthAkt/PKBPI3KmTORC1

Open questions that cite this study

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Cite this paper

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Rommel, C., et al. (2001). Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways. Nature Cell Biology. https://doi.org/10.1038/ncb1101-1009

@article{ROM2001,
  author       = {Rommel, C. and Bodine, S. C. and others},
  title        = {{Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways}},
  journal      = {Nature Cell Biology},
  year         = {2001},
  doi          = {10.1038/ncb1101-1009},
  note         = {PMID: 11715022},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record ROM2001) [Data set]. https://mtor-atlas.org/study/ROM2001/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_ROM2001,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record ROM2001},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/ROM2001/},
  doi          = {10.5281/zenodo.22059963}
}