Muscle growth

Biological process · 3 studies in the Atlas

mTORC1-dependent process of skeletal muscle fiber enlargement (hypertrophy); driven by growth factors and exercise, blocked by rapamycin.

Evidence at a glance

Tier	What it means	Studies
B	Direct human evidence	2
D	Mechanistic / in vitro / review	1

Studies

Study	Year	Tier	Finding
MOE2025	2025	B	First completed long-term RCT of rapamycin for healthy human aging (NCT04488601, 48 weeks, n=114). Primary endpoint (visceral fat by DXA) showed NO significant change (p=0.942) - a null result exactly
DRU2009	2009	B	Rapamycin given before resistance exercise completely blocked the normal post-exercise increase in human muscle protein synthesis.
ROM2001	2001	D	Shows IGF-1 drives muscle fiber hypertrophy specifically through the Akt-mTOR pathway, establishing mTORC1 as a central node for muscle growth signaling.

Related entities

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