Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate

mTORC2 (mammalian target of rapamycin complex 2) plays important roles in signal transduction by regulating an array of downstream effectors, including protein kinase AKT. However, its regulation by upstream regulators remains poorly characterized. Although phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) is known to regulate the phosphorylation of AKT Ser(473), the hydrophobic motif (HM) site, by mTORC2, it is not clear whether PtdIns(3,4,5)P(3) can directly regulate mTORC2 kinase activity.

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Gan, X., et al. (2011). Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate. The Journal of biological chemistry. https://doi.org/10.1074/jbc.M110.195016

@article{GAN2011,
  author       = {Gan, X. and Wu, D. and others},
  title        = {{Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate}},
  journal      = {The Journal of biological chemistry},
  year         = {2011},
  doi          = {10.1074/jbc.M110.195016},
  note         = {PMID: 21310961},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record GAN2011) [Data set]. https://mtor-atlas.org/study/GAN2011/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_GAN2011,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record GAN2011},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/GAN2011/},
  doi          = {10.5281/zenodo.22059963}
}