Activation of mTORC2 by association with the ribosome

Zinzalla V, Stracka D, Oppliger W, Hall MN · 2011 · Cell · Atlas ID ZIN2011

What this study shows

mTORC2 is activated by direct association with the ribosome downstream of PI3K.

Abstract

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The target of rapamycin (TOR) is a highly conserved protein kinase and a central controller of growth. Mammalian TOR complex 2 (mTORC2) regulates AGC kinase family members and is implicated in various disorders, including cancer and diabetes. Here, we investigated the upstream regulation of mTORC2. A genetic screen in yeast and subsequent studies in mammalian cells revealed that ribosomes, but not protein synthesis, are required for mTORC2 signaling.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mammalian cells
Journal	Cell
Year	2011
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1016/j.cell.2011.02.014 · PMID 21376236

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Genetic/biochemical (mTORC2 / ribosome)
Target	mTORC2 / ribosome / Akt
Model	Mammalian cells
Effect	mTORC2 is activated by direct association with the ribosome (PI3K-dependent)

In the Atlas

Links in the pathway map

Supports PI3K activates mTORC2

Cite this paper

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Zinzalla, V., Stracka, D., Oppliger, W., & Hall, M. N. (2011). Activation of mTORC2 by association with the ribosome. Cell. https://doi.org/10.1016/j.cell.2011.02.014

@article{ZIN2011,
  author       = {Zinzalla, V. and Stracka, D. and Oppliger, W. and Hall, M. N.},
  title        = {{Activation of mTORC2 by association with the ribosome}},
  journal      = {Cell},
  year         = {2011},
  doi          = {10.1016/j.cell.2011.02.014},
  note         = {PMID: 21376236},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record ZIN2011) [Data set]. https://mtor-atlas.org/study/ZIN2011/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_ZIN2011,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record ZIN2011},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/ZIN2011/},
  doi          = {10.5281/zenodo.22059963}
}

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