Pathway link PI3K-MTORC2
PI3K mTORC2
PI3K activates mTORC2.
The same lipid signal that switches Akt on also switches mTORC2 on – so growth-factor signals hit both complexes.
The conditions it holds under
Growth-factor dependence of mTORC2 assembly and activity, shown in mammalian cells. The ribosome requirement (ZIN2011) means the readout is not a clean separation of PI3K input from translational state.
- Time it takes
- seconds
- Step
- indirect (through steps not drawn here)
- Measured in
- mammalian cells
- Where in the cell
- plasma membrane
- Reaches people?
- plausible in people, not shown directly
- How settled
- emerging, few independent studies
Studies behind it
| Year | Evidence | Study |
|---|---|---|
| 2015 | M | PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase ComplexLIU2015 PIP3 relieves SIN1 PH-domain autoinhibition to activate the mTORC2 kinase complex. |
| 2011 | M | Activation of mTORC2 by association with the ribosomeZIN2011 mTORC2 is activated by direct association with the ribosome downstream of PI3K. |
| 2012 | M | A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulationDAL2012 A time-resolved, data-fitted model of the whole core insulin-mTOR network, including the mTORC1 negative feedback loop onto PI3K. Perturbing it in silico and in cells showed that TSC1-TSC2 is not a regulator of mTORC2, directly or through the feedback loop, and that mTORC2 activation runs through a PI3K variant insensitive to that loop. One of the few places where the feedback loops in the atlas are treated as a dynamical system rather than a diagram. |
| 2011 | M | Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphateGAN2011 PIP3 directly stimulates mTORC2 kinase activity, linking PI3K to mTORC2. |
Points the other way
No study in the Atlas contradicts this link. That means none in this curated set, not none in the literature.
Who has checked this
- Checked by
- No researcher outside the project has checked this link yet.
- Curator sign-off
- Not signed off yet. This link was drafted with AI help and has not been reviewed link by link; treat it as a proposal until it is.
- Curated by
- Oliver Barton, with AI help for drafting; see how links are checked.
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