Oliver's mTOR Atlas Evidence Platform
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PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex

Liu P, Wei W et al. · 2015 · Cancer discovery · Atlas ID LIU2015

What this study shows

PIP3 relieves SIN1 PH-domain autoinhibition to activate the mTORC2 kinase complex.

Abstract

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mTOR serves as a central regulator of cell growth and metabolism by forming two distinct complexes, mTORC1 and mTORC2. Although mechanisms of mTORC1 activation by growth factors and amino acids have been extensively studied, the upstream regulatory mechanisms leading to mTORC2 activation remain largely elusive. Here, we report that the pleckstrin homology (PH) domain of SIN1, an essential and unique component of mTORC2, interacts with the mTOR kinase domain to suppress mTOR activity.

Read the full abstract on PubMed →

At a glance

Evidence type M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type5 - Mechanistic / In Vitro
Model systemMammalian cells
JournalCancer discovery
Year2015
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1158/2159-8290.CD-15-0460 · PMID 26293922 · Free full text (PMC4631654)

Extracted findings

InterventionBiochemical/genetic (SIN1 PH domain)
TargetmTORC2 / SIN1 / PtdIns(3,4,5)P3
ModelMammalian cells
EffectPIP3 binds the SIN1 PH domain to relieve suppression of mTOR → activates mTORC2

Cite this paper

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Liu, P., et al. (2015). PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex. Cancer discovery. https://doi.org/10.1158/2159-8290.CD-15-0460

@article{LIU2015,
  author       = {Liu, P. and Wei, W. and others},
  title        = {{PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex}},
  journal      = {Cancer discovery},
  year         = {2015},
  doi          = {10.1158/2159-8290.CD-15-0460},
  note         = {PMID: 26293922},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record LIU2015) [Data set]. https://mtor-atlas.org/study/LIU2015/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_LIU2015,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record LIU2015},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/LIU2015/},
  doi          = {10.5281/zenodo.22059963}
}