Xiaoqing Gan
Biochemist at Fudan University who showed as a Yale postdoc that the lipid messenger PIP3 directly switches on mTORC2, and who now studies Wnt and mTORC2 signalling in metabolism
Researcher, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University (since 2013) · postdoc, Yale University School of Medicine (2009–2013) · PhD in Biochemistry and Molecular Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (2008)
mTORC2 is the second mTOR complex. One of its main jobs is to switch on Akt, a kinase that tells cells to take up sugar, grow and survive. By 2011 it was known that growth factors acting through PI3K turn on mTORC2, but not how. PI3K makes a lipid called PIP3 in the cell membrane. In the Atlas study GAN2011, Xiaoqing Gan, working in Dianqing Wu's lab at Yale, showed in cultured cells and in test-tube kinase assays that PIP3 directly raises the activity of mTORC2. This gave a simple chemical link between PI3K and mTORC2.
Gan earned a PhD in biochemistry and molecular biology at the Shanghai Institutes for Biological Sciences of the Chinese Academy of Sciences in 2008 and was a postdoc at Yale University School of Medicine from 2009 to 2013.
Since 2013 Gan has been a researcher (principal investigator) in the Department of Biochemistry and Molecular Biology of the School of Basic Medical Sciences at Fudan University in Shanghai. The group works on metabolism and cell signalling, with themes that include Wnt signalling in stem cell differentiation, communication between bone and brown fat, and G protein-coupled receptor and mTORC2 signalling.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2011 | M | Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate GAN2011 First author: showed in cells and in kinase assays that the lipid PIP3 directly stimulates mTORC2, linking PI3K to mTORC2. |
Co-authors in the Atlas 2
People with a profile here who share at least one study with Xiaoqing Gan.
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- Bing Su Immunologist who studies how mTOR and MAPK signaling shape immune regulation and vascular function, and senior author of the study showing that SIN1 is a core part of mTORC2.
- Dianqing (Dan) Wu Signalling biologist who studies Wnt signalling and receptor-driven cell migration, and who showed that PIP3 can directly stimulate mTORC2 kinase activity.
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