Oliver's mTOR Atlas Evidence Platform
Reading level
Mode

TORC1 inhibition enhances immune function and reduces infections in the elderly

Mannick JB, Morris M, Hockey HP, Roma G, Beibel M, Klickstein LB · 2018 · Science Translational Medicine · Atlas ID MAN2018

What this study shows

The strongest human evidence that mTOR inhibition can rejuvenate a specific function of aging - immunity. In 264 elderly people, a low-dose combination that selectively hits TORC1 significantly reduced infections over the following year and boosted antiviral gene expression and flu-vaccine response. The follow-up to Mannick 2014.

Abstract

ShowHide

Inhibition of the mechanistic target of rapamycin (mTOR) protein kinase extends life span and ameliorates aging-related pathologies including declining immune function in model organisms. The objective of this phase 2a randomized, placebo-controlled clinical trial was to determine whether low-dose mTOR inhibitor therapy enhanced immune function and decreased infection rates in 264 elderly subjects given the study drugs for 6 weeks.

Read the full abstract on PubMed →

At a glance

Evidence type H Human study Marked H because it is direct evidence from a human clinical trial or human cohort; the code names the kind of study, not its quality -- a small, well-run trial is still H.
Study type2 - Human Clinical Trial
Model systemHumans, phase 2a RCT (n=264, elderly)
JournalScience Translational Medicine
Year2018
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1126/scitranslmed.aaq1564 · PMID 29997249

Extracted findings

InterventionLow-dose mTOR inhibitor (RAD001 + RTB101/BEZ235), 6 weeks
TargetTORC1
ModelHuman – phase 2a RCT (n=264, elderly)
EffectCombined low-dose TORC1 inhibition enhanced immune function and reduced infection rates in the elderly

In the Atlas

Related topics

EverolimusImmune functionmTORC1RTB101

Open questions that cite this study

Answers that reference this study

More studies on this topic

Cite this paper

ShowHide 
Mannick, J. B., Morris, M., Hockey, H. P., Roma, G., Beibel, M., & Klickstein, L. B. (2018). TORC1 inhibition enhances immune function and reduces infections in the elderly. Science Translational Medicine. https://doi.org/10.1126/scitranslmed.aaq1564

@article{MAN2018,
  author       = {Mannick, J. B. and Morris, M. and Hockey, H. P. and Roma, G. and Beibel, M. and Klickstein, L. B.},
  title        = {{TORC1 inhibition enhances immune function and reduces infections in the elderly}},
  journal      = {Science Translational Medicine},
  year         = {2018},
  doi          = {10.1126/scitranslmed.aaq1564},
  note         = {PMID: 29997249},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record MAN2018) [Data set]. https://mtor-atlas.org/study/MAN2018/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_MAN2018,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record MAN2018},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/MAN2018/},
  doi          = {10.5281/zenodo.22059963}
}