BMAL1-dependent regulation of the mTOR signaling pathway delays aging

The circadian clock, an internal time-keeping system, has been linked with control of aging, but molecular mechanisms of regulation are not known. BMAL1 is a transcriptional factor and core component of the circadian clock; BMAL1 deficiency is associated with premature aging and reduced lifespan. Here we report that activity of mammalian Target of Rapamycin Complex 1 (mTORC1) is increased upon BMAL1 deficiency both in vivo and in cell culture.

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Khapre, R. V., Kondratova, A. A., Patel, S., Dubrovsky, Y., Wrobel, M., Antoch, M. P., & Kondratov, R. V. (2014). BMAL1-dependent regulation of the mTOR signaling pathway delays aging. Aging (Albany NY). https://doi.org/10.18632/aging.100633

@article{KHA2014,
  author       = {Khapre, R. V. and Kondratova, A. A. and Patel, S. and Dubrovsky, Y. and Wrobel, M. and Antoch, M. P. and Kondratov, R. V.},
  title        = {{BMAL1-dependent regulation of the mTOR signaling pathway delays aging}},
  journal      = {Aging (Albany NY)},
  year         = {2014},
  doi          = {10.18632/aging.100633},
  note         = {PMID: 24481314},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record KHA2014) [Data set]. https://mtor-atlas.org/study/KHA2014/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_KHA2014,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record KHA2014},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/KHA2014/},
  doi          = {10.5281/zenodo.22059963}
}