Testing efficacy of administration of the antiaging drug rapamycin in a nonhuman primate, the common marmoset.

Tardif S, Ross C, Bergman P, Fernandez E, Javors M, Salmon AB, Spross J, Strong R, Richardson A · 2014 · The Journals of Gerontology: Series A · Atlas ID TAR2014

What this study shows

First description of dosing, pharmacokinetics, biochemical action and tolerability of rapamycin in the common marmoset. Eudragit-encapsulated rapamycin given orally at roughly 1.0 mg/kg/day gave mean trough blood levels of 5.2 ng/mL (range 1.93-10.73), comparable to rodent studies and within the human therapeutic range. In long-term animals (6 of 8) the phospho-rpS6 to total rpS6 ratio fell after 2 weeks, and rapamycin was detectable in liver and adipose tissue with reduced mTOR signalling there. There was no evidence of clinical anemia, fibrotic lung changes or mouth ulcers, and the death rate in the 14-month study was as expected for the animals' ages. Boundary: small cohort (6 of 8 long-term animals showed the pS6 drop), a 3-week and a 14-month study, pharmacology and tolerability only; no lifespan or healthspan outcome was measured, and nothing here is tested in people.

Abstract

ShowHide

This report is the first description of dosing procedures, pharmacokinetics, biochemical action, and general tolerability of the antiaging drug rapamycin in the common marmoset, a small and short-lived monkey. Eudragit-encapsulated rapamycin was given orally to trained marmosets in a short-term (3 weeks) and a long-term (14 months) study. Circulating trough rapamycin levels (mean = 5.2 ng/mL; 1.93-10.73 ng/mL) achieved at roughly 1.0 mg/kg/day was comparable to those reported in studies of rodents and within the therapeutic range for humans.

Read the full abstract on PubMed →

At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Common marmoset (Callithrix jacchus), oral Eudragit-encapsulated rapamycin, short-term (3 weeks) and long-term (14 months) studies); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Common marmoset (Callithrix jacchus), oral Eudragit-encapsulated rapamycin, short-term (3 weeks) and long-term (14 months) studies
Journal	The Journals of Gerontology: Series A
Year	2014
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1093/gerona/glu101 · PMID 25038772 · Free full text (PMC4400395)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Oral Eudragit-encapsulated rapamycin, roughly 1.0 mg/kg/day, 3 weeks (short-term) and 14 months (long-term)
Target	mTORC1 signalling (phospho-rpS6/total rpS6) in liver and adipose tissue
Model	Common marmoset (Callithrix jacchus)
Effect	Blood levels in the human therapeutic range; reduced mTORC1 signalling in 6 of 8 long-term animals; well tolerated

In the Atlas

Cite this paper

ShowHide

Tardif, S., Ross, C., Bergman, P., Fernandez, E., Javors, M., Salmon, A. B., Spross, J., Strong, R., & Richardson, A. (2014). Testing efficacy of administration of the antiaging drug rapamycin in a nonhuman primate, the common marmoset. The Journals of Gerontology: Series A. https://doi.org/10.1093/gerona/glu101

@article{TAR2014,
  author       = {Tardif, S. and Ross, C. and Bergman, P. and Fernandez, E. and Javors, M. and Salmon, A. B. and Spross, J. and Strong, R. and Richardson, A.},
  title        = {{Testing efficacy of administration of the antiaging drug rapamycin in a nonhuman primate, the common marmoset}},
  journal      = {The Journals of Gerontology: Series A},
  year         = {2014},
  doi          = {10.1093/gerona/glu101},
  note         = {PMID: 25038772},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record TAR2014) [Data set]. https://mtor-atlas.org/study/TAR2014/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_TAR2014,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record TAR2014},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/TAR2014/},
  doi          = {10.5281/zenodo.22059963}
}

Was this page useful?