Oliver's mTOR Atlas Evidence Platform
Reading level
Mode

Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls

Bannister CA et al. · 2014 · Diabetes, Obesity and Metabolism · Atlas ID BAN2014

What this study shows

Diabetic patients started on metformin had longer median survival than matched non-diabetic controls without the drug. Retrospective and observational: consistent with a survival benefit, but confounding by indication and healthy-adherer effects cannot be excluded.

Abstract

ShowHide

Clinical and observational studies have shown an increased risk of cardiovascular events and death associated with sulphonylureas versus metformin. However, it has never been determined whether this was due to the beneficial effects of metformin or detrimental effects of sulphonylureas. The objective of this study was therefore to compare all-cause mortality in diabetic patients treated first-line with either sulphonylurea or metformin monotherapy with that in matched individuals without diabetes.

Read the full abstract on PubMed →

At a glance

Evidence type H Human study Marked H because it is direct evidence from a human clinical trial or human cohort; the code names the kind of study, not its quality -- a small, well-run trial is still H.
Study type3 - Human Observational
Model systemHumans, retrospective cohort (n=180,926)
JournalDiabetes, Obesity and Metabolism
Year2014
Peer reviewedYes
Record last updated2026-07-29
SourceDOI 10.1111/dom.12354 · PMID 25041462

Extracted findings

InterventionMetformin (vs sulphonylurea) monotherapy
TargetAMPK / mTOR (indirect)
ModelHuman – retrospective cohort (n=180,926)
EffectMetformin-treated diabetics had lower all-cause mortality than sulphonylurea users and even matched non-diabetic controls

In the Atlas

Related topics

LongevityMetformin

Open questions that cite this study

Answers that reference this study

More studies on this topic

Cite this paper

ShowHide 
Bannister, C. A., et al. (2014). Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls. Diabetes, Obesity and Metabolism. https://doi.org/10.1111/dom.12354

@article{BAN2014,
  author       = {Bannister, C. A. and others},
  title        = {{Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls}},
  journal      = {Diabetes, Obesity and Metabolism},
  year         = {2014},
  doi          = {10.1111/dom.12354},
  note         = {PMID: 25041462},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record BAN2014) [Data set]. https://mtor-atlas.org/study/BAN2014/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_BAN2014,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record BAN2014},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/BAN2014/},
  doi          = {10.5281/zenodo.22059963}
}