Metformin

Drug · 3 studies in the Atlas

Antidiabetic drug; activates AMPK and indirectly inhibits mTORC1.

Evidence at a glance

Tier	What it means	Studies
B	Direct human evidence	1
D	Mechanistic / in vitro / review	2

Studies

Study	Year	Tier	Finding
BAN2014	2014	B	Diabetic patients started on metformin had longer median survival than matched non-diabetic controls without the drug.
HOW2017	2017	D	Pinned down HOW the diabetes drug metformin - a major longevity candidate - actually reaches mTOR. In the liver, metformin lowers cellular energy, and at low doses this shuts down mTORC1 specifically
ZHO2001	2001	D	Metformin activates AMPK, suppressing hepatic gluconeogenesis and lipogenesis.

Related entities

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