Association of rapamycin treatment with the modulation of purine metabolism, reduced microglial inflammatory responses, improved mitochondrial energy metabolism, and alleviation of fatigue symptoms in ME/CFS subjects: pilot findings from phase-II observational study

Phase II observational pilot trial. Low-dose rapamycin significantly reduced fatigue symptoms in ME/CFS subjects. LCMS-based quantification revealed differential regulation of purine biosynthetic intermediates (IMP to XMP and HPX pathway). Rapamycin reduces IMP dehydrogenase activity, limiting IMP to XMP conversion. Altered purine levels impair mitochondrial energy metabolism and contribute to microglial inflammation. No placebo group; results biased to responders. NCT06257420.

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Brooke Gile, Sarojini Bulbule, Mubaraq A Toriola, Brian T Ruan, Shabnam Marium, Anna Benko, Stephanie Grach, Michael Mueller, Lucinda Bateman, Jennifer Bell, Brayden Yellman, Jon Berner, Bela Chheda, David Kaufman, Gunnar Gottschalk, & Avik Roy (2026). Association of rapamycin treatment with the modulation of purine metabolism, reduced microglial inflammatory responses, improved mitochondrial energy metabolism, and alleviation of fatigue symptoms in ME/CFS subjects: pilot findings from phase-II observational study. Journal of Translational Medicine. https://doi.org/10.1186/s12967-026-08575-3

@article{GIL2026,
  author       = {Brooke Gile and Sarojini Bulbule and Mubaraq A Toriola and Brian T Ruan and Shabnam Marium and Anna Benko and Stephanie Grach and Michael Mueller and Lucinda Bateman and Jennifer Bell and Brayden Yellman and Jon Berner and Bela Chheda and David Kaufman and Gunnar Gottschalk and Avik Roy},
  title        = {{Association of rapamycin treatment with the modulation of purine metabolism, reduced microglial inflammatory responses, improved mitochondrial energy metabolism, and alleviation of fatigue symptoms in ME/CFS subjects: pilot findings from phase-II observational study}},
  journal      = {Journal of Translational Medicine},
  year         = {2026},
  doi          = {10.1186/s12967-026-08575-3},
  note         = {PMID: 42432754},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record GIL2026) [Data set]. https://mtor-atlas.org/study/GIL2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_GIL2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record GIL2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/GIL2026/},
  doi          = {10.5281/zenodo.22059963}
}