Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

The immunosuppressive drug, rapamycin, interferes with an undefined signaling pathway required for the progression of G1-phase T-cells into S phase. Genetic analyses in yeast indicate that binding of rapamycin to its intracellular receptor, FKBP12, generates a toxic complex that inhibits cell growth in G1 phase. These analyses implicated two related proteins, TOR1 and TOR2, as targets of the FKBP12-rapamycin complex in yeast.

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Sabers, C. J., et al. (1995). Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. The Journal of biological chemistry. https://doi.org/10.1074/jbc.270.2.815

@article{SAB1995,
  author       = {Sabers, C. J. and Abraham, R. T. and others},
  title        = {{Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells}},
  journal      = {The Journal of biological chemistry},
  year         = {1995},
  doi          = {10.1074/jbc.270.2.815},
  note         = {PMID: 7822316},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record SAB1995) [Data set]. https://mtor-atlas.org/study/SAB1995/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_SAB1995,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record SAB1995},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/SAB1995/},
  doi          = {10.5281/zenodo.22059963}
}