Mammalian target of rapamycin signaling in cardiac physiology and disease

The protein kinase mammalian or mechanistic target of rapamycin (mTOR) is an atypical serine/threonine kinase that exerts its main cellular functions by interacting with specific adaptor proteins to form 2 different multiprotein complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). mTORC1 regulates protein synthesis, cell growth and proliferation, autophagy, cell metabolism, and stress responses, whereas mTORC2 seems to regulate cell survival and polarity. The mTOR pathway plays a key regulatory function in cardiovascular physiology and pathology.

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Sciarretta, S., Volpe, M., & Sadoshima, J. (2014). Mammalian target of rapamycin signaling in cardiac physiology and disease. Circulation research. https://doi.org/10.1161/CIRCRESAHA.114.302022

@article{SCI2014,
  author       = {Sciarretta, S. and Volpe, M. and Sadoshima, J.},
  title        = {{Mammalian target of rapamycin signaling in cardiac physiology and disease}},
  journal      = {Circulation research},
  year         = {2014},
  doi          = {10.1161/CIRCRESAHA.114.302022},
  note         = {PMID: 24481845},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record SCI2014) [Data set]. https://mtor-atlas.org/study/SCI2014/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_SCI2014,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record SCI2014},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/SCI2014/},
  doi          = {10.5281/zenodo.22059963}
}