mTOR substrate phosphorylation in growth control

The target of rapamycin (TOR), discovered 30 years ago, is a highly conserved serine/threonine protein kinase that plays a central role in regulating cell growth and metabolism. It is activated by nutrients, growth factors, and cellular energy. TOR forms two structurally and functionally distinct complexes, TORC1 and TORC2. TOR signaling activates cell growth, defined as an increase in biomass, by stimulating anabolic metabolism while inhibiting catabolic processes. With emphasis on mammalian TOR (mTOR), we comprehensively reviewed the literature and identified all reported direct substrates.

Read the full abstract on PubMed →

Battaglioni, S., et al. (2022). mTOR substrate phosphorylation in growth control. Cell. https://doi.org/10.1016/j.cell.2022.04.013

@article{BAT2022,
  author       = {Battaglioni, S. and Hall, M. N. and others},
  title        = {{mTOR substrate phosphorylation in growth control}},
  journal      = {Cell},
  year         = {2022},
  doi          = {10.1016/j.cell.2022.04.013},
  note         = {PMID: 35580586},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record BAT2022) [Data set]. https://mtor-atlas.org/study/BAT2022/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_BAT2022,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record BAT2022},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/BAT2022/},
  doi          = {10.5281/zenodo.22059963}
}