The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

To fulfill the bioenergetic and biosynthetic demand of proliferation, T cells reprogram their metabolic pathways from fatty acid beta-oxidation and pyruvate oxidation via the TCA cycle to the glycolytic, pentose-phosphate, and glutaminolytic pathways. Two of the top-ranked candidate transcription factors potentially responsible for the activation-induced T cell metabolic transcriptome, HIF1alpha and Myc, were induced upon T cell activation, but only the acute deletion of Myc markedly inhibited activation-induced glycolysis and glutaminolysis in T cells.

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Wang, R., et al. (2011). The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity. https://doi.org/10.1016/j.immuni.2011.09.021

@article{WAN2011,
  author       = {Wang, R. and Green, D. R. and others},
  title        = {{The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation}},
  journal      = {Immunity},
  year         = {2011},
  doi          = {10.1016/j.immuni.2011.09.021},
  note         = {PMID: 22195744},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record WAN2011) [Data set]. https://mtor-atlas.org/study/WAN2011/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_WAN2011,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record WAN2011},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/WAN2011/},
  doi          = {10.5281/zenodo.22059963}
}