The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

Wang R, Dillon CP, Shi LZ, Milasta S, Carter R, Finkelstein D, McCormick LL, Fitzgerald P, Chi H, Munger J, Green DR · 2011 · Immunity · Atlas ID WAN2011

What this study shows

The transcription factor Myc drives metabolic reprogramming of activated T cells downstream of mTOR.

Abstract

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To fulfill the bioenergetic and biosynthetic demand of proliferation, T cells reprogram their metabolic pathways from fatty acid beta-oxidation and pyruvate oxidation via the TCA cycle to the glycolytic, pentose-phosphate, and glutaminolytic pathways. Two of the top-ranked candidate transcription factors potentially responsible for the activation-induced T cell metabolic transcriptome, HIF1alpha and Myc, were induced upon T cell activation, but only the acute deletion of Myc markedly inhibited activation-induced glycolysis and glutaminolysis in T cells.

Read the full abstract on PubMed →

At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Mouse); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Mouse
Journal	Immunity
Year	2011
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1016/j.immuni.2011.09.021 · PMID 22195744 · Free full text (PMC3248798)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Genetic (Myc)
Target	Myc (mTOR-linked metabolism)
Model	Mouse T cells
Effect	Myc controls the metabolic reprogramming (glycolysis, glutaminolysis) upon T-lymphocyte activation
Dose	not stated
Sample size	not stated
Effect size	not stated
Limitations	not stated

In the Atlas

Cite this paper

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Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., & Green, D. R. (2011). The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity. https://doi.org/10.1016/j.immuni.2011.09.021

@article{WAN2011,
  author       = {Wang, R. and Dillon, C. P. and Shi, L. Z. and Milasta, S. and Carter, R. and Finkelstein, D. and McCormick, L. L. and Fitzgerald, P. and Chi, H. and Munger, J. and Green, D. R.},
  title        = {{The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation}},
  journal      = {Immunity},
  year         = {2011},
  doi          = {10.1016/j.immuni.2011.09.021},
  note         = {PMID: 22195744},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record WAN2011) [Data set]. https://mtor-atlas.org/study/WAN2011/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_WAN2011,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record WAN2011},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/WAN2011/},
  doi          = {10.5281/zenodo.22059963}
}

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