Rapamycin Attenuates Age-Related Changes in Marmoset Submandibular Gland: A Non-Human Primate Model of Human Oral Aging.

Abdul-Azees PA, Wang H, Chen J, Marinkovic M, Dean DD, Chen XD, Salmon AB, Yeh CK · 2026 · Aging and Disease · Atlas ID ABD2026

What this study shows

In the aging marmoset submandibular gland the authors found fewer mucous and serous acinar units, expansion of ductal and collagen-rich stromal compartments, more extracellular matrix remodeling, dysregulated lipid metabolism, and more apoptotic and senescent cells. Chronic oral rapamycin was associated with partial preservation of acinar structure and with less fibrosis, lipid accumulation and fewer apoptotic and senescent cells, giving a tissue picture closer to that of younger animals. Boundary: histological and immunofluorescence associations in one tissue of a short-lived primate; the abstract gives no dose or group sizes, does not show that gland function improved, and reports no lifespan outcome.

Abstract

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The aging of salivary glands (SGs) leads to xerostomia, impaired oral defenses, and a compromised quality of life, yet the biology of human submandibular gland (SMG) aging remains poorly understood due to limited availability of human tissues and differences in anatomy and physiology between rodent and human SGs. The common marmoset (Callithrix jacchus) is a short-lived non-human primate (NHP) with SMG histology that closely resembles humans and has the potential to provide a translational model for investigating SG aging.

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At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Common marmoset (Callithrix jacchus), chronic oral rapamycin, submandibular gland histology and immunofluorescence); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Common marmoset (Callithrix jacchus), chronic oral rapamycin, submandibular gland histology and immunofluorescence
Journal	Aging and Disease
Year	2026
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.14336/AD.2026.0057 · PMID 42372235

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Chronic oral rapamycin
Target	Age-related structure of the submandibular gland (acini, fibrosis, lipid, apoptosis, senescence)
Model	Common marmoset (Callithrix jacchus)
Effect	Partial preservation of acinar structure; less fibrosis, lipid accumulation, apoptosis and senescence

In the Atlas

Cite this paper

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Abdul-Azees, P. A., Wang, H., Chen, J., Marinkovic, M., Dean, D. D., Chen, X. D., Salmon, A. B., & Yeh, C. K. (2026). Rapamycin Attenuates Age-Related Changes in Marmoset Submandibular Gland: A Non-Human Primate Model of Human Oral Aging. Aging and Disease. https://doi.org/10.14336/AD.2026.0057

@article{ABD2026,
  author       = {Abdul-Azees, P. A. and Wang, H. and Chen, J. and Marinkovic, M. and Dean, D. D. and Chen, X. D. and Salmon, A. B. and Yeh, C. K.},
  title        = {{Rapamycin Attenuates Age-Related Changes in Marmoset Submandibular Gland: A Non-Human Primate Model of Human Oral Aging}},
  journal      = {Aging and Disease},
  year         = {2026},
  doi          = {10.14336/AD.2026.0057},
  note         = {PMID: 42372235},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record ABD2026) [Data set]. https://mtor-atlas.org/study/ABD2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_ABD2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record ABD2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/ABD2026/},
  doi          = {10.5281/zenodo.22059963}
}

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